Prof. Dr. Dr. Michael Frühwald
Publikationen
2024
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2023
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2022
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2021
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2020
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2019
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2018
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2017
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2016
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2015
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2014
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2013
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2012
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2011
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2010
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2009
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2008
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2007
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2006
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2004
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2003
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2002
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2001
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2000
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1999
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1998
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2024 |
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Kelety Tibor, Thomale Ulrich‐Wilhelm, Kandels Daniela, Schuhmann Martin U., El Damaty Ahmed, Krauss Jürgen, Frühwald Michael C., Hernáiz Driever Pablo, Witt Olaf, Bison Brigitte, Warmuth‐Metz Monika, Pietsch Torsten, Schmidt René, Gnekow Astrid K..
Adaption of neurosurgical resection patterns for pediatriclow-grade glioma spanning two decades: report from the German LGG-studies 1996–2018.
https://doi.org/10.1002/cam4.7417
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Feuchtinger Tobias, Bader Peter, Subklewe Marion, Breidenbach Maike, Willier Semjon, Metzler Markus, Gökbuget Nicola, Hauer Julia, Müller Fabian, Schlegel Paul-Gerhardt, Frühwald Michael C., Schmid Christoph, Troeger Anja, Baldus Claudia, Meisel Roland, Künkele Annette, Topp Max, Bourquin Jean-Pierre, Cario Gunnar, Von Stackelberg Arend, Peters Christina.
Approaches for bridging therapy prior to chimeric antigen receptor T cells for relapsed/refractory acute lymphoblastic B-lineage leukaemia in children and young adults.
https://doi.org/10.3324/haematol.2023.283780
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Kaffai Stefanie, Angelova-Toshkin Daniela, Weins Andreas B., Ickinger Sonja, Steinke-Lange Verena, Vollert Kurt, Frühwald Michael C., Kuhlen Michaela.
Cancer predisposing syndromes in childhood and adolescence pose several challenges necessitating interdisciplinary care in dedicated programs.
https://doi.org/10.3389/fped.2024.1410061
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Fincke Victoria E., Steinbügl Mona, Chun Hye-Jung E., Nemes Karolina, Mucha Marlena, Loßner Maurice, Dorn Felix, Gastberger Katharina, Bühner Sebastian, Sill Martin, Kröncke Thomas, Siebert Reiner, Melchior Patrick, Furtwängler Rhoikos, Schlesner Matthias, Vokuhl Christian, Röcken Christoph, Johann Pascal D., Frühwald Michael C..
Clinical and molecular risk factors in extracranial malignant rhabdoid tumors: toward an integrated model of high-risk tumors.
https://doi.org/10.1158/1078-0432.ccr-23-3489
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Kuhlen Michaela, Schaller Tina, Dintner Sebastian, Stadler Nicole, Hofmann Thomas G., Schmutz Maximilian, Claus Rainer, Frühwald Michael C., Golas Monika M..
Double heterozygous pathogenic variants in TP53 and CHEK2 in boy with undifferentiated embryonal sarcoma of the liver.
https://doi.org/10.3390/ijms252111489
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Mercante Anna, Owens Judith, Bruni Oliviero, Nunes Magda L., Gringras Paul, Li Shirley Xin, Papa Simonetta, Kreicbergs Ulrika, Wolfe Joanne, Zernikow Boris, Lacerda Ana, Benini Franca, Li Albert, Wolfson Amy R., Marinetto Anna, Santini Anna, Zanin Anna, Kuhn Brett R., Angelhoff Charlotte, Santos Cristiane Fumo dos, Goh Daniel Y.T., Verrillo Elisabetta, Zhou Eric S., Ferreira Esther Angélica Luiz, Bergstraesser Eva, Pizza Fabio, Nilsson Frans, Plazzi Giuseppe, Wang Guanghai, Traslaviña Guillermo Andrey Ariza, Moreira Gustavo Antonio, Siden Hal, Hauch Holger, Huijer Huda Abu-Saad, Catalano Igor, Narang Indra, Avagnina Irene, Lopez Jaime Gutierrez Del Alamo, Wille Joakim, Mindell Jodi, Bogetz Jori, Downing Julia, Hauer Julie, Streuli Jürg, Baker Justin, Spruyt Karen, Chan Kate Ching Ching, Soster Leticia Azevedo, Oliveira Lia, Ragsdale Lindsay, Nobili Lino, Matlen Lisa, Nosetti Luana, De Zen Lucia, Strambi Luigi Ferini, Stenmarker Margaretha, Lopes Maria Cecilia, Blankenburg Markus, Rios Marta, Bernadá Mercedes, Farquhar Michael, Frühwald Michael C., Gradisar Michael, Simakajornboon Narong, Lazzarin Pierina, Chong Poh-Heng, Ferri Raffaele, Martino-Alba Ricardo, Findling Robert L., Ferreira Rosário, Bin-Hasan Saadoun, Kudchadkar Sapna R., Mercadante Sebastiano, Amarri Sergio, Keenan Sharon, Noce Silvia, de Oliveira Iglesias Simone Brasil, Fagondes Simone, Suh Sooyeon, Sheldon Stephen H., Sejersen Thomas, Ceranoglu Tolga Atilla, Crabtree Valerie, Castronovo Vincenza.
International consensus on sleep problems in pediatric palliative care: paving the way.
https://doi.org/10.1016/j.sleep.2024.05.042
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Corbacioglu Selim, Lode Holger, Ellinger Susanne, Zeman Florian, Suttorp Meinolf, Escherich Gabriele, Bochennek Konrad, Gruhn Bernd, Lang Peter, Rohde Marius, Debatin Klaus Michael, Steinbach Daniel, Beilken Andreas, Ladenstein Ruth, Spachtholz Rainer, Heiss Peter, Hellwig Dirk, Tröger Anja, Koller Michael, Menhart Karin, Riemenschneider Markus J., Zoubaa Saida, Kietz Silke, Jakob Marcus, Sommer Gunhild, Heise Tilman, Hundsdörfer Patrick, Kühnle Ingrid, Dilloo Dagmar, Schönberger Stefan, Schwabe Georg, von Luettichau Irene, Graf Norbert, Schlegel Paul-Gerhardt, Frühwald Michael C., Jorch Norbert, Paulussen Michael, Schneider Dominik T., Metzler Markus, Leipold Alfred, Nathrath Michaela, Imschweiler Thomas, Christiansen Holger, Schmid Irene, Crazzolara Roman, Niktoreh Naghmeh, Cario Gunnar, Faber Joerg, Demmert Martin, Babor Florian, Fröhlich Birgit, Bielack Stefan, Bernig Toralf, Greil Johann, Eggert Angelika, Simon Thorsten, Foell Juergen.
Irinotecan and temozolomide in combination with dasatinib and rapamycin versus irinotecan and temozolomide for patients with relapsed or refractory neuroblastoma (RIST-rNB-2011): a multicentre, open-label, randomised, controlled, phase 2 trial.
https://doi.org/10.1016/s1470-2045(24)00202-x
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Kuhlen Michaela, Kunstreich Marina, Pape Ulrich-Frank, Seitz Guido, Lessel Lienhard, Vokuhl Christian, Frühwald Michael C., Vorwerk Peter, Redlich Antje.
Lymph node metastases are more frequent in paediatric appendiceal NET ≥1.5 cm but without impact on outcome – data from the German MET studies.
https://doi.org/10.1016/j.ejso.2024.108051
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Flaadt Tim, Wild Hannah, Abele Michael, Frühwald Michael C., Dirksen Uta, Classen Carl F., Seitz Christian, Redlich Antje, Lauer Ulrich M., Kloker Linus, Kratz Christian, Schneider Dominik T., Brecht Ines B..
NUT carcinoma in pediatric patients: characteristics, therapeutic regimens, and outcomes of 11 cases registered with the German Registry for Rare Pediatric Tumors (STEP).
https://doi.org/10.1002/pbc.30821
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Hau Peter, Frühwald Michael C..
Platform trials for rare cancers: a complex innovation to accelerate knowledge.
https://doi.org/10.1093/nop/npae035
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Traunwieser Thomas, Loos Elena, Ottensmeier Holger, Mynarek Martin, Bison Brigitte, Kandels Daniela, Rossius Anne, Lüttich Peggy, Baust Katja, Faulstich-Ritter Kristin, John Rainer, Kreisch Andrea, Landmann Judyta, Manteufel Eva, Nest Alexandra, Prüfe Jenny, Schubert Lisa, Stamm Walther, Timmermann Beate, Gerss Joachim, Rutkowski Stefan, Schlegel Paul-Gerhardt, Eyrich Matthias, Gnekow Astrid K., Frühwald Michael C..
QOL-31. Neuropsychological functioning and quality of life in infant AT/RT survivors: focus on fluid intelligence and visual processing [Abstract].
https://doi.org/10.1093/neuonc/noae064.619
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Frisch Sabine, Libuschewski Hanna, Peters Sarah, Gerß Joachim, von Hoff Katja, Kortmann Rolf-Dieter, Nemes Karolina, Rutkowski Stefan, Hasselblatt Martin, Pietsch Torsten, Frühwald Michael C., Timmermann Beate.
Radiation therapy plays an important role in the treatment of atypical teratoid/rhabdoid tumors: analysis of the EU-RHAB cohorts and their precursors.
https://doi.org/10.1016/j.ijrobp.2024.01.200
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Hasselblatt Martin, Kool Marcel, Frühwald Michael C..
SWI/SNF-deficient tumors of the central nervous system: an update.
https://doi.org/10.5414/np301594
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Erlacher Miriam, Andresen Felicia, Sukova Martina, Stary Jan, De Moerloose Barbara, Bosch Jutte van der Werff Ten, Dworzak Michael, Seidel Markus G., Polychronopoulou Sophia, Beier Rita, Kratz Christian M., Nathrath Michaela, Frühwald Michael C., Göhring Gudrun, Bergmann Anke K., Mayerhofer Christina, Lebrecht Dirk, Ramamoorthy Senthilkumar, Yoshimi Ayami, Strahm Brigitte, Wlodarski Marcin W., Niemeyer Charlotte M..
Spontaneous remission and loss of monosomy 7: a window of opportunity for young children with SAMD9L syndrome.
https://doi.org/10.3324/haematol.2023.283591
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Traunwieser Thomas, Loos Elena, Ottensmeier Holger, Gastberger Katharina, Nemes Karolina, Mynarek Martin, Bison Brigitte, Kandels Daniela, Neumayer Petra, Neumann‐Holbeck Anne, Lüttich Peggy, Baust Katja, Faulstich‐Ritter Kristin, John Rainer, Kreisch Andrea, Landmann Judyta, Manteufel Eva, Nest Alexandra, Prüfe Jenny, Schubert Lisa, Stamm Walther, Timmermann Beate, Gerss Joachim, Rutkowski Stefan, Schlegel Paul‐Gerhardt, Eyrich Matthias, Gnekow Astrid K., Frühwald Michael C..
Survivors of infant atypical teratoid/rhabdoid tumors present with severely impaired cognitive functions especially for fluid intelligence and visual processing: data from the German brain tumor studies.
https://doi.org/10.1002/pbc.30910
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Wegert Jenny, Fischer Anne Kristin, Palhazi Balazs, Treger Taryn D., Hilgers Cäcilia, Ziegler Barbara, Jung Hyunchul, Jüttner Eva, Waha Andreas, Fuchs Jörg, Warmann Steven W., Frühwald Michael C., Hubertus Jochen, Pritchard‐Jones Kathy, Graf Norbert, Behjati Sam, Furtwängler Rhoikos, Gessler Manfred, Vokuhl Christian.
TRIM28 inactivation in epithelial nephroblastoma is frequent and often associated with predisposing TRIM28 germline variants.
https://doi.org/10.1002/path.6206
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Filippidou Maria, Glentis Stavros, Binenbaum Ilona, Sill Martin, Roka Kleoniki, Vlachou Antonia, Avgerinou Georgia, Ecker Jonas, Selt Florian, Hasselblatt Martin, Blattner-Johnson Mirjam, Schramm Kathrin, Trougkou Clio, Doganis Dimitrios, Katzilakis Nikolaos, Ridola Vita, Papakonstantinou Evgenia, Papadakis Vassilios, Hatzipantelis Emmanouel, Kokkinou Eleftheria, Pons Roser, Kanaka-Gantenbein Christina, Sturm Dominik, Hirsch Steffen, Dikow Nicola, Pajtler Kristian W., van Tilburg Cornelis M., Frühwald Michael C., Milde Till, Witt Olaf, Jones David T. W., Von Deimling Andreas, Sahm Felix, Stefanaki Kalliopi, Pfister Stefan M., Kattamis Antonis.
The impact of methylome analysis on the diagnosis and treatment of CNS tumours in children and adolescents: a population-based study in Greece.
https://doi.org/10.1016/j.ejcped.2024.100198
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2023 |
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Brugmans Aliska K., Walter Carolin, Moreno Natalia, Göbel Carolin, Holdhof Dörthe, de Faria Flavia W., Hotfilder Marc, Jeising Daniela, Frühwald Michael C., Skryabin Boris V., Rozhdestvensky Timofey S., Wachsmuth Lydia, Faber Cornelius, Dugas Martin, Varghese Julian, Schüller Ulrich, Albert Thomas K., Kerl Kornelius.
A carboxy-terminal SMARCB1 point mutation induces hydrocephalus formation and affects AP-1 and neuronal signalling pathways in mice.
https://doi.org/10.1007/s10571-023-01361-5
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Kuhlen Michaela, Golas Mariola Monika, Schaller Tina, Stadler Nicole, Maier Felicitas, Witt Olaf, Frühwald Michael C..
Beyond germline genetic testing - heterozygous pathogenic variants in PMS2 in two children with osteosarcoma and ependymoma.
https://doi.org/10.1186/s13053-023-00254-4
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Schillok Hannah, Coenen Michaela, Rehfuess Eva A., Kuhlmann Pia H., Matl Stefan, Kindermann Hannah, Maison Nicole, Eckert Jana, von Both Ulrich, Behrends Uta, Frühwald Michael C., Neubert Antje, Woelfle Joachim, Melter Michael, Liese Johannes, Hübner Johannes, Klein Christoph, Kern Anna, Jung-Sievers Caroline.
Changes in behavior and quality of life in German young children during the COVID-19 pandemic—results from the COVID kids bavaria study.
https://doi.org/10.3389/fped.2023.1135415
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Angelova-Toshkina Daniela, Decker Josua A., Traunwieser Thomas, Holzapfel Johannes, Bette Stefanie, Huber Simon, Schimmel Mareike, Vollert Kurt, Bison Brigitte, Kröncke Thomas, Bramswig Nuria C., Wieczorek Dagmar, Gnekow Astrid Katharina, Frühwald Michael C., Kuhlen Michaela.
Comprehensive neurological evaluation of a cohort of patients with neurofibromatosis type 1 from a single institution.
https://doi.org/10.1016/j.ejpn.2023.02.006
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Gastberger Katharina, Fincke Victoria, Mucha Marlena, Siebert Reiner, Hasselblatt Martin, Frühwald Michael C..
Current molecular and clinical landscape of ATRT: the link to future therapies.
https://doi.org/10.2147/cmar.s379451
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Kubek Larissa Alice, Claus Benedikt, Rostasy Kevin, Bertolini Annikki, Schimmel Mareike, Frühwald Michael C., Classen Georg, Zernikow Boris, Wager Julia.
Development and preliminary validation of the sleep screening for children and adolescents with complex chronic conditions (SCAC).
https://doi.org/10.1111/jsr.13881
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Aridgides Paul D., Mahajan Anita, Eaton Bree, Wang Dongliang, Timmerman Beate, Frühwald Michael C., Nemes Karolina, Deck Jared, Yamasaki Kai, Von Hoff Katja, Lafay‐Cousin Lucie, Reddy Alyssa, Lo Andrea C..
Focal versus craniospinal radiation for disseminated atypical teratoid/rhabdoid tumor following favorable response to systemic therapy.
https://doi.org/10.1002/pbc.30351
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Kuhlen Michaela, Mier Pascal, Kunstreich Marina, Lessel Lienhard, Slavetinsky Christoph, Fuchs Jörg, Seitz Guido, Holterhus Paul-Martin, Wudy Stefan A., Vokuhl Christian, Frühwald Michael C., Vorwerk Peter, Redlich Antje.
Locally advanced adrenocortical carcinoma in children and adolescents — enigmatic and challenging cases.
https://doi.org/10.3390/cancers15174296
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Kuhlen Michaela, Kunstreich Marina, Wudy Stefan A., Holterhus Paul-Martin, Lessel Lienhard, Schneider Dominik T., Brecht Ines B., Schewe Denis M., Seitz Guido, Roecken Christoph, Vokuhl Christian, Johann Pascal-David, Frühwald Michael C., Vorwerk Peter, Redlich Antje.
Outcome for pediatric adreno-cortical tumors is best predicted by the COG stage and five-item microscopic score — report from the German MET studies.
https://doi.org/10.3390/cancers15010225
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Johann Pascal-David, Altendorf Lea, Efremova Emma-Maria, Holsten Till, Steinbügl Mona, Nemes Karolina, Eckhardt Alicia, Kresbach Catena, Bockmayr Michael, Koch Arend, Haberler Christine, Antonelli Manila, DeSisto John, Schuhmann Martin U., Hauser Peter, Siebert Reiner, Bens Susanne, Kool Marcel, Green Adam L., Hasselblatt Martin, Frühwald Michael C., Schüller Ulrich.
Recurrent atypical teratoid/rhabdoid tumors (AT/RT) reveal discrete features of progression on histology, epigenetics, copy number profiling, and transcriptomics.
https://doi.org/10.1007/s00401-023-02608-7
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Kuhlen Michaela, Kunstreich Marina, Lessel Lienhard, Wudy Stefan A., Holterhus Paul-Martin, Vokuhl Christian, Juettner Eva, Roecken Christoph, Seitz Guido, Slavetinsky Christoph, Fuchs Jörg, Schewe Denis M., Claus Rainer, Johann Pascal-David, Frühwald Michael C., Vorwerk Peter, Redlich Antje.
Refractory and relapsed paediatric ACC in the MET studies – a challenging situation necessitating novel diagnostic and therapeutic concepts.
https://doi.org/10.1016/j.ejcped.2023.100015
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Nemes Karolina, Benesch Martin, Kolarova Julia, Johann Pascal-David, Hasselblatt Martin, Thomas Christian, Bens Susanne, Glaser Selina, Ammerpohl Ole, Liaugaudiene Olga, Sadeghipour Alireza, von der Weid Nicolas, Schmid Irene, Gidding Corrie, Erdreich-Epstein Anat, Khurana Claudia, Ebetsberger-Dachs Georg, Lemmer Andreas, Khatib Ziad, Hernández Marqués Carmen, Pears Jane, Quehenberger Franz, Kordes Uwe, Vokuhl Christian, Gerss Joachim, Schwarz Heike, Bison Brigitte, Biegel Jaclyn A., Siebert Reiner, Frühwald Michael C..
Rhabdoid tumors in patients conceived following ART: is there an association?.
https://doi.org/10.1093/humrep/dead154
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Polutta Amelie, Reinhardt Dirk, Baruchel Andre, Hasle Henrik, Locatelli Franco, Zwaan C. Michel, Frühwald Michael C., Westphal Silke, Dworzak Michael, Boztug Heidrun, Escherich Gabriele, Lehrnbecher Thomas, Goemans Bianca F., Strahm Brigitte, Schneider Markus, Hoffmeister Lina, Waack Katharina.
Treatment of molecular relapses in pediatric AML saves toxicities prior to hematopoietic stem cell transplant (HSCT) - results of AMoRe2017 trial [Abstract].
https://doi.org/10.1182/blood-2023-180820
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Kertels Olivia, Krauß Jürgen, Monoranu Camelia Maria, Samnick Samuel, Dierks Alexander, Kircher Malte, Mihovilovic Milena I., Pham Mirko, Buck Andreas K., Eyrich Matthias, Schlegel Paul-Gerhardt, Frühwald Michael C., Bison Brigitte, Lapa Constantin.
[18F]FET-PET in children and adolescents with central nervous system tumors: does it support difficult clinical decision-making?.
https://doi.org/10.1007/s00259-023-06114-6
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2022 |
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Dogan Meltem, Hirschfeld Gerrit, Blankenburg Markus, Frühwald Michael C., Ahnert Rosemarie, Braun Sarah, Marschall Ursula, Zernikow Boris, Wager Julia.
A randomized controlled trial on long‐term effectiveness of a psychosocial aftercare program following paediatric chronic pain treatment: who benefits the most?.
https://doi.org/10.1002/ejp.1998
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Traunwieser Thomas, Loos Elena, Nemes Karolina, Kandels Daniela, Neumayer Petra, Neumann-Holbeck Anne, Lüttich Peggy, Baust Katja, Faulstich-Ritter Kristin, John Rainer, Kreisch Andrea, Manteufel Eva, Nest Alexandra, Prüfe Jenny, Schubert Lisa, Siebrands Joy, Stamm Walther, Timmermann Beate, Gerss Joachim, Gnekow Astrid K., Frühwald Michael C..
ATRT-02. Neuropsychological function in infant atypical teratoid/rhabdoid tumor versus low-grade glioma survivors reflects tumor malignancy and multimodal treatment [Abstract].
https://doi.org/10.1093/neuonc/noac079.001
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Federico Aniello, Thomas Christian, Miskiewicz Katarzyna, Woltering Niklas, Zin Francesca, Nemes Karolina, Bison Brigitte, Johann Pascal-David, Hawes Debra, Bens Susanne, Kordes Uwe, Albrecht Steffen, Dohmen Hildegard, Hauser Peter, Keyvani Kathy, van Landeghem Frank K. H., Lund Eva Løbner, Scheie David, Mawrin Christian, Monoranu Camelia-Maria, Parm Ulhøi Benedicte, Pietsch Torsten, Reinhard Harald, Riemenschneider Markus J., Sehested Astrid, Sumerauer David, Siebert Reiner, Paulus Werner, Frühwald Michael C., Kool Marcel, Hasselblatt Martin.
ATRT–SHH comprises three molecular subgroups with characteristic clinical and histopathological features and prognostic significance.
https://doi.org/10.1007/s00401-022-02424-5
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Kuhlen Michaela, Pamporaki Christina, Kunstreich Marina, Wudy Stefan A., Hartmann Michaela F., Peitzsch Mirko, Vokuhl Christian, Seitz Guido, Kreissl Michael C., Simon Thorsten, Hero Barbara, Frühwald Michael C., Vorwerk Peter, Redlich Antje.
Adrenocortical tumors and pheochromocytoma/paraganglioma initially mistaken as neuroblastoma — experiences from the GPOH-MET registry.
https://doi.org/10.3389/fendo.2022.918435
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Redlich Antje, Luster Markus, Lorenz Kerstin, Lessel Lienhard, Rohrer Tilman, Schmid Kurt W., Frühwald Michael C., Vorwerk Peter, Kuhlen Michaela.
Age, ATA risk group and response to therapy are prognostic factors in children with differentiated thyroid cancer.
https://doi.org/10.1210/clinem/dgab622
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Tüchert Stefanie E., Nemes Karolina, Frühwald Michael C., Vollert Kurt, Kröncke Thomas.
Bildgebung extrakranieller Maligner Rhabdoider Tumoren.
https://doi.org/10.1055/a-1843-9207
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Nemes Karolina, Johann Pascal-David, Tüchert Stefanie, Melchior Patrick, Vokuhl Christian, Siebert Reiner, Furtwängler Rhoikos, Frühwald Michael C..
Current and emerging therapeutic approaches for extracranial malignant rhabdoid tumors.
https://doi.org/10.2147/cmar.s289544
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de Faria Flavia W., Walter Carolin, Interlandi Marta, Melcher Viktoria, Riedel Nicole, Graf Monika, Moreno Natalia, Schoof Melanie, Holdhof Doerthe, Thomas Christian, Frühwald Michael C., Märkl Bruno, Ho Ben, Sandmann Sarah, Varghese Julian, Ebinger Martin, Schuhmann Martin, Canak Ayseguel, Huang Annie, Schüller Ulrich, Albert Thomas K., Kerl Kornelius.
ETMR-05: Single-cell transcriptomics of ETMR reveals developmental cellular programs and tumor-pericyte communications in the microenvironment [Abstract].
https://doi.org/10.1093/neuonc/noac079.183
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Dogan Meltem, Hartenstein-Pinter Almut, Lopez Lumbi Susanne, Blankenburg Markus, Frühwald Michael C., Ahnert Rosemarie, Braun Sarah, Marschall Ursula, Zernikow Boris, Wager Julia.
Exploring the mechanisms underlying the effectiveness of psychosocial aftercare in pediatric chronic pain treatment: a qualitative approach.
https://doi.org/10.3390/children9030407
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Penkert Judith, Strüwe Farina J., Dutzmann Christina M., Doergeloh Beate B., Montellier Emilie, Freycon Claire, Keymling Myriam, Schlemmer Heinz-Peter, Sänger Birte, Hoffmann Beatrice, Gerasimov Tanja, Blattmann Claudia, Fetscher Sebastian, Frühwald Michael C., Hettmer Simone, Kordes Uwe, Ridola Vita, Kroiss Benninger Sabine, Mastronuzzi Angela, Schott Sarah, Nees Juliane, Prokop Aram, Redlich Antje, Seidel Markus G., Zimmermann Stefanie, Pajtler Kristian W., Pfister Stefan M., Hainaut Pierre, Kratz Christian P..
Genotype–phenotype associations within the Li-Fraumeni spectrum: a report from the German Registry.
https://doi.org/10.1186/s13045-022-01332-1
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Sparber‐Sauer Monika, Vokuhl Christian, Seitz Guido, Sorg Benjamin, Möllers Tobias, Kalle Thekla, Münter Marc, Bielack Stefan S., Ladenstein Ruth, Ljungman Gustaf, Niggli Felix, Frühwald Michael C., Loff Stefan, Klingebiel Thomas, Koscielniak Ewa.
Infantile myofibromatosis: excellent prognosis but also rare fatal progressive disease: treatment results of five Cooperative Weichteilsarkom Studiengruppe (CWS) trials and one registry.
https://doi.org/10.1002/pbc.29403
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Nemes Karolina, Johann Pascal-David, Steinbügl Mona, Gruhle Miriam, Bens Susanne, Kachanov Denis, Teleshova Margarita, Hauser Peter, Simon Thorsten, Tippelt Stephan, Eberl Wolfgang, Chada Martin, Lopez Vicente Santa-Maria, Grigull Lorenz, Hernáiz-Driever Pablo, Eyrich Matthias, Pears Jane, Milde Till, Reinhard Harald, Leipold Alfred, van de Wetering Marianne, Gil-da-Costa Maria João, Ebetsberger-Dachs Georg, Kerl Kornelius, Lemmer Andreas, Boztug Heidrun, Furtwängler Rhoikos, Kordes Uwe, Vokuhl Christian, Hasselblatt Martin, Bison Brigitte, Kröncke Thomas, Melchior Patrick, Timmermann Beate, Gerss Joachim, Siebert Reiner, Frühwald Michael C..
Infants and newborns with Atypical Teratoid Rhabdoid Tumors (ATRT) and Extracranial Malignant Rhabdoid Tumors (eMRT) in the EU-RHAB registry: a unique and challenging population.
https://doi.org/10.3390/cancers14092185
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Kuhlen Michaela, Mier Pascal, Kunstreich Marina, Lessel Lienhard, Schneider Dominik, Brecht Ines, Schewe Denis M., Frühwald Michael C., Vorwerk Peter, Redlich Antje.
Key factors for effective mitotane therapy in children with adrenocortical carcinoma.
https://doi.org/10.1530/erc-22-0146
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Leone Vincenza, Meisinger Christa, Temizel Selin, Kling Elisabeth, Gerstlauer Michael, Frühwald Michael C., Burkhardt Katrin.
Longitudinal change in SARS-CoV-2 seroprevalence in 3-to 16-year-old children: the Augsburg Plus study.
https://doi.org/10.1371/journal.pone.0272874
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Hasselblatt Martin, Thomas Christian, Federico Aniello, Bens Susanne, Hellström Mats, Casar‐Borota Olivera, Kordes Uwe, Neumann Julia E., Dottermusch Matthias, Rodriguez Fausto J., Lo Andrea C., Cheng Sylvia, Hendson Glenda, Hukin Juliette, Hartmann Christian, Koch Arend, Capper David, Siebert Reiner, Paulus Werner, Nemes Karolina, Johann Pascal-David, Frühwald Michael C., Kool Marcel.
Low‐grade diffusely infiltrative tumour (LGDIT), SMARCB1‐mutant: a clinical and histopathological distinct entity showing epigenetic similarity with ATRT‐MYC.
https://doi.org/10.1111/nan.12797
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Benesch M., Perwein T., Apfaltrer G., Langer T., Neumann A., Brecht I.B., Schuhmann M.U., Cario H., Frühwald Michael C., Vollert Kurt, van Buiren M., Deng M.Y., Seitz A., Haberler C., Mynarek M., Kramm C., Sahm F., Robe P.A., Dankbaar J.W., Hoff K.V., Warmuth-Metz M., Bison Brigitte.
MR Imaging and clinical characteristics of diffuse glioneuronal tumor with oligodendroglioma-like features and nuclear clusters.
https://doi.org/10.3174/ajnr.a7647
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Angelova-Toshkina Daniela, Holzapfel Johannes, Huber Simon, Schimmel Mareike, Wieczorek Dagmar, Gnekow Astrid K., Frühwald Michael C., Kuhlen Michaela.
Neurofibromatosis type 1: a comparison of the 1997 NIH and the 2021 revised diagnostic criteria in 75 children and adolescents.
https://doi.org/10.1016/j.gim.2022.05.013
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Angelova-Toshkina Daniela, Holzapfel Johannes, Bette Stefanie, Decker Josua, Hellmann Fabio, Traunwieser Thomas, Huber Simon, Schimmel Mareike, Vollert Kurt, Bison Brigitte, Kroencke Thomas, André Elisabeth, Wieczorek Dagmar, Gnekow Astrid Katharina, Frühwald Michael C., Kuhlen Michaela.
Neurological manifestations in children and adolescents with neurofibromatosis type-1-implications for management and surveillance [Abstract].
https://doi.org/10.1093/neuonc/noac079.467
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Krieg Sandro M., Bernhard Denise, Ille Sebastian, Meyer Bernhard, Combs Stephanie, Rotenberg Alexander, Frühwald Michael C..
Neurosurgery for eloquent lesions in children: state-of-the-art rationale and technical implications of perioperative neurophysiology.
https://doi.org/10.3171/2022.9.focus22316
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Blümel Lena, Qin Nan, Berlandi Johannes, Paisana Eunice, Cascão Rita, Custódia Carlos, Pauck David, Picard Daniel, Langini Maike, Stühler Kai, Meyer Frauke-Dorothee, Göbbels Sarah, Malzkorn Bastian, Liebau Max C., Barata João T., Jeibmann Astrid, Kerl Kornelius, Erkek Serap, Kool Marcel, Pfister Stefan M., Johann Pascal-David, Frühwald Michael C., Borkhardt Arndt, Reifenberger Guido, Faria Claudia C., Fischer Ute, Hasselblatt Martin, Bartl Jasmin, Remke Marc.
Primary cilia contribute to the aggressiveness of atypical teratoid/rhabdoid tumors.
https://doi.org/10.1038/s41419-022-05243-4
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Peters Sarah, Frisch Sabine, Stock Annika, Merta Julien, Bäumer Christian, Blase Christoph, Schuermann Eicke, Tippelt Stephan, Bison Brigitte, Frühwald Michael C., Rutkowski Stefan, Fleischhack Gudrun, Timmermann Beate.
Proton beam therapy for pediatric tumors of the central nervous system — experiences of clinical outcome and feasibility from the KiProReg Study.
https://doi.org/10.3390/cancers14235863
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Fincke Victoria E., Krulik Mateja E., Joshi Piyush, Frühwald Michael C., Chen Ying-Bei, Johann Pascal-David.
Renal medullary carcinomas harbor a distinct methylation phenotype and display aberrant methylation of genes related to early nephrogenesis.
https://doi.org/10.3390/cancers14205044
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Hasselblatt Martin, Thomas Christian, Federico Aniello, Nemes Karolina, Johann Pascal-David, Bison Brigitte, Bens Susanne, Dahlum Sonja, Kordes Uwe, Redlich Antje, Lessel Lienhard, Pajtler Kristian W., Mawrin Christian, Schüller Ulrich, Nolte Kay, Kramm Christof M., Hinz Felix, Sahm Felix, Giannini Caterina, Penkert Judith, Kratz Christian P., Pfister Stefan M., Siebert Reiner, Paulus Werner, Kool Marcel, Frühwald Michael C..
SMARCB1-deficient and SMARCA4-deficient malignant brain tumors with complex copy number alterations and TP53 mutations may represent the first clinical manifestation of Li-Fraumeni syndrome.
https://doi.org/10.1097/pas.0000000000001905
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Graf Monika, Interlandi Marta, Moreno Natalia, Holdhof Dörthe, Göbel Carolin, Melcher Viktoria, Mertins Julius, Albert Thomas K., Kastrati Dennis, Alfert Amelie, Holsten Till, de Faria Flavia, Meisterernst Michael, Rossig Claudia, Warmuth-Metz Monika, Nowak Johannes, Meyer zu Hörste Gerd, Mayère Chloe, Nef Serge, Johann Pascal-David, Frühwald Michael C., Dugas Martin, Schüller Ulrich, Kerl Kornelius.
Single-cell transcriptomics identifies potential cells of origin of MYC rhabdoid tumors.
https://doi.org/10.1038/s41467-022-29152-4
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Kern Anna, Kuhlmann Pia H., Matl Stefan, Ege Markus, Maison Nicole, Eckert Jana, von Both Ulrich, Behrends Uta, Anger Melanie, Frühwald Michael C., Gerstlauer Michael, Woelfle Joachim, Neubert Antje, Melter Michael, Liese Johannes, Goettler David, Sing Andreas, Liebl Bernhard, Hübner Johannes, Klein Christoph.
Surveillance of acute SARS-CoV-2 infections in elementary schools and daycare facilities in Bavaria, Germany (09/2020–03/2021).
https://doi.org/10.3389/fped.2022.888498
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Huber Simon, Schimmel Mareike, Dunstheimer Désirée, Nemes Karolina, Richter Markus, Streble Joachim, Vollert Kurt, Walden Ulrike, Frühwald Michael C., Kuhlen Michaela.
The need for tumor surveillance of children and adolescents with cancer predisposition syndromes: a retrospective cohort study in a tertiary-care children’s hospital.
https://doi.org/10.1007/s00431-021-04347-x
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Andresen Felicia, Sukova Martina, Stary Jan, De Mörloose Barbara, Van Der Werff Ten Bosch Jutte, Dworzak Michael, Seidel Markus G., Polychronopoulou Sophia, Beier Rita, Kratz Christian P., Nathrath Michaela, Frühwald Michael C., Göhring Gudrun, Bergmann Anke K., Mayerhofer Christina, Rotari Natalia, Lebrecht Dirk, Ramamoorthy Senthilkumar, Yoshimi Ayami, Strahm Brigitte, Wlodarski Marcin W., Niemeyer Charlotte M., Erlacher Miriam.
Transient monosomy 7 is a rare event in young children with SAMD9L syndrome [Abstract].
https://doi.org/10.1182/blood-2022-159221
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2021 |
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Jordan Frank, Huber Simon, Sommer Sebastian, Schenkirsch Gerhard, Frühwald Michael C., Trepel Martin, Claus Rainer, Kuhlen Michaela.
A retrospective 5-year single center study highlighting the risk of cancer predisposition in adolescents and young adults.
https://doi.org/10.3390/cancers13123033
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Beck Lydia, Witt Ruth, Nesper‐Brock Martina, Milde Till, Hettmer Simone, Frühwald Michael C., Rössig Claudia, Fischer Matthias, Reinhardt Dirk, Taylor Lenka A., Riedel Claudia, Witt Olaf, Tilburg Cornelis M..
A study of regulatory challenges of pediatric oncology phase I/II trial submissions and guidance on protocol development.
https://doi.org/10.1002/cpt.2319
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Redlich Antje, Luster Markus, Lorenz Kerstin, Lessel Lienhard, Rohrer Tilman R., Schmid Kurt W., Frühwald Michael C., Vorwerk Peter, Kuhlen Michaela.
Age, American Thyroid Association Risk Group, and response to therapy are prognostic factors in children with differentiated thyroid cancer.
https://doi.org/10.1210/clinem/dgab622
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Thomas Christian, Federico Aniello, Sill Martin, Bens Susanne, Oyen Florian, Nemes Karolina, Johann Pascal-David, Hartmann Christian, Hartmann Wolfgang, Sumerauer David, Paterno Vincenzo, Samii Amir, Kordes Uwe, Siebert Reiner, Frühwald Michael C., Paulus Werner, Kool Marcel, Hasselblatt Martin.
Atypical teratoid/rhabdoid tumor (AT/RT) with molecular features of pleomorphic xanthoastrocytoma.
https://doi.org/10.1097/pas.0000000000001694
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Nemes Karolina, Bens Susanne, Kachanov Denis, Teleshova Margarita, Hauser Peter, Simon Thorsten, Tippelt Stephan, Woessmann Wilhelm, Beck Olaf, Flotho Christian, Grigull Lorenz, Driever Pablo H., Schlegel Paul-Gerhardt, Khurana Claudia, Hering Kathrin, Kolb Reinhard, Leipold Alfred, Abbink Floor, Gil-Da-Costa Maria J., Benesch Martin, Kerl Kornelius, Lowis Stephen, Marques Carmen H., Graf Norbert, Nysom Karsten, Vokuhl Christian, Melchior Patrick, Kröncke Thomas, Schneppenheim Reinhard, Kordes Uwe, Gerss Joachim, Siebert Reiner, Furtwängler Rhoikos, Frühwald Michael C..
Clinical and genetic risk factors define two risk groups of extracranial malignant rhabdoid tumours (eMRT/RTK).
https://doi.org/10.1016/j.ejca.2020.10.004
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Berthold Frank, Rosswog Carolina, Christiansen Holger, Frühwald Michael C., Hemstedt Nadine, Klingebiel Thomas, Fröhlich Birgit, Schilling Freimut H., Schmid Irene, Simon Thorsten, Hero Barbara, Fischer Matthias, Ernst Angela.
Clinical and molecular characterization of patients with stage 4(M) neuroblastoma aged less than 18 months without MYCN amplification.
https://doi.org/10.1002/pbc.29038
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Steinbügl Mona, Nemes Karolina, Johann Pascal-David, Kröncke Thomas, Tüchert Stefanie, da Costa Maria Joao Gil, Ebinger Martin, Schüller Ulrich, Sehested Astrid, Hauser Peter, Reinhard Harald, Sumerauer David, Hettmer Simone, Jakob Marcus, Hasselblatt Martin, Siebert Reiner, Witt Olaf, Gerss Joachim, Kerl Kornelius, Frühwald Michael C..
Clinical evidence for a biological effect of epigenetically active decitabine in relapsed or progressive rhabdoid tumors.
https://doi.org/10.1002/pbc.29267
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Frühwald Michael C., Nemes K., Boztug H., Cornips M. C. A., Evans D. G., Farah R., Glentis S., Jorgensen M., Katsibardi K., Hirsch S., Jahnukainen K., Kventsel I., Kerl K., Kratz C. P., Pajtler K. W., Kordes U., Ridola V., Stutz E., Bourdeaut F..
Current recommendations for clinical surveillance and genetic testing in rhabdoid tumor predisposition: a report from the SIOPE host genome working group.
https://doi.org/10.1007/s10689-021-00229-1
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Dogan Meltem, Hirschfeld Gerrit, Blankenburg Markus, Frühwald Michael C., Ahnert Rosemarie, Braun Sarah, Marschall Ursula, Pfenning Ingo, Zernikow Boris, Wager Julia.
Effectiveness of a psychosocial aftercare program for youth aged 8 to 17 years with severe chronic pain: a randomized clinical trial.
https://doi.org/10.1001/jamanetworkopen.2021.27024
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Berken Jonas, Losher E., Zerwes Sebastian, Linné R., Frühwald Michael C., Anthuber Matthias, Hyhlik-Dürr Alexander.
Ethische Aspekte in der Aortenchirurgie: ein Fallbericht.
https://doi.org/10.1007/s00772-020-00719-z
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Kordes Uwe, Mautner Victor‐Felix, Oyen Florian, Hagel Christian, Hartmann Christian, Heuser Michael, Frühwald Michael C., Hasselblatt Martin, Oehl‐Huber Kathrin, Siebert Reiner, Schneppenheim Reinhard, Schüller Ulrich.
Evidence for a low‐penetrant extended phenotype of rhabdoid tumor predisposition syndrome type 1 from a kindred with gain of SMARCB1 exon 6.
https://doi.org/10.1002/pbc.29185
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Jazmati D., Steinmeier T., Ahamd Khalil D., Frisch S., Peters S., Schulze Schleithoff S., Bäumer C., Rutkowski S., Frühwald Michael C., Blase C., Tippelt S., Timmermann B..
Feasibility of proton beam therapy for infants with brain tumours: experiences from the prospective KiProReg registry study.
https://doi.org/10.1016/j.clon.2021.03.006
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Mehaffey Carla, Wahl Dagmar, Schaller Tina, Blattner-Johnson Mirjam, Claus Rainer, Frühwald Michael C., Kuhlen Michaela.
Heterozygous PALB2 mutation in a boy with acute lymphoblastic leukemia and subsequent metastatic Ewing sarcoma.
https://doi.org/10.1055/a-1404-3243
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Zierk Jakob, Baum Hannsjörg, Bertram Alexander, Boeker Martin, Buchwald Armin, Cario Holger, Christoph Jürgen, Frühwald Michael C., Groß Hans-Jürgen, Groening Arndt, Gscheidmeier Thomas, Hoff Torsten, Hoffmann Reinhard, Klauke Rainer, Krebs Alexander, Lichtinghagen Ralf, Mühlenbrock-Lenter Sabine, Neumann Michael, Nöllke Peter, Niemeyer Charlotte M., Ruf Hans-Georg, Steigerwald Udo, Streichert Thomas, Torge Antje, Yoshimi-Nöllke Ayami, Prokosch Hans-Ulrich, Metzler Markus, Rauh Manfred.
High-resolution pediatric reference intervals for 15 biochemical analytes described using fractional polynomials.
https://doi.org/10.1515/cclm-2020-1371
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Zin Francesca, Cotter Jennifer A., Haberler Christine, Dottermusch Matthias, Neumann Julia, Schüller Ulrich, Schweizer Leonille, Thomas Christian, Nemes Karolina, Johann Pascal-David, Kool Marcel, Frühwald Michael C., Paulus Werner, Judkins Alexander, Hasselblatt Martin.
Histopathological patterns in atypical teratoid/rhabdoid tumors are related to molecular subgroup.
https://doi.org/10.1111/bpa.12967
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Mayr Franz X., Bertram Alexander, Cario Holger, Frühwald Michael C., Groß Hans-Jürgen, Groening Arndt, Grützner Stefanie, Gscheidmeier Thomas, Hoffmann Reinhard, Krebs Alexander, Ruf Hans-Georg, Torge Antje, Woelfle Joachim, Razum Oliver, Rauh Manfred, Metzler Markus, Zierk Jakob.
Influence of Turkish origin on hematology reference intervals in the German population.
https://doi.org/10.1038/s41598-021-00566-2
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Pathak Rajiv, Zin Francesca, Thomas Christian, Bens Susanne, Gayden Tenzin, Karamchandani Jason, Dudley Roy W., Nemes Karolina, Johann Pascal-David, Oyen Florian, Kordes Uwe, Jabado Nada, Siebert Reiner, Paulus Werner, Kool Marcel, Frühwald Michael C., Albrecht Steffen, Kalpana Ganjam V., Hasselblatt Martin.
Inhibition of nuclear export restores nuclear localization and residual tumor suppressor function of truncated SMARCB1/INI1 protein in a molecular subset of atypical teratoid/rhabdoid tumors.
https://doi.org/10.1007/s00401-021-02328-w
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Adolph Jonas E., Fleischhack Gudrun, Mikasch Ruth, Zeller Julia, Warmuth-Metz Monika, Bison Brigitte, Mynarek Martin, Rutkowski Stefan, Schüller Ulrich, von Hoff Katja, Obrecht Denise, Pietsch Torsten, Pfister Stefan M., Pajtler Kristian W., Witt Olaf, Witt Hendrik, Kortmann Rolf-Dieter, Timmermann Beate, Krauß Jürgen, Frühwald Michael C., Faldum Andreas, Kwiecien Robert, Bode Udo, Tippelt Stephan.
Local and systemic therapy of recurrent ependymoma in children and adolescents: short- and long-term result of the E-HIT-REZ 2005 study.
https://doi.org/10.1093/neuonc/noaa276
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Maier Felicitas, Frühwald Michael C., Heinrich Uwe, Schimmel Mareike, Wahl Dagmar, Eggermann Thomas.
Overgrowth-associated partial trisomy 15q24.3-qter and mosaic 11p15.5 duplication involving Silver-Russell region in a patient with lateralized asymmetry and developmental delay.
https://doi.org/10.1097/mcd.0000000000000378
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Redlich Antje, Pamporaki Christina, Lessel Lienhard, Frühwald Michael C., Vorwerk Peter, Kuhlen Michaela.
Pseudohypoxic pheochromocytomas and paragangliomas dominate in children.
https://doi.org/10.1002/pbc.28981
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Andrianteranagna Mamy, Cyrta Joanna, Masliah‐Planchon Julien, Nemes Karolina, Corsia Alice, Leruste Amaury, Holdhof Dörthe, Kordes Uwe, Orbach Daniel, Corradini Nadège, Entz‐Werle Natacha, Pierron Gaëlle, Castex Marie‐Pierre, Brouchet Anne, Weingertner Noëlle, Ranchère Dominique, Fréneaux Paul, Delattre Olivier, Bush Jonathan, Leary Alexandra, Frühwald Michael C., Schüller Ulrich, Servant Nicolas, Bourdeaut Franck.
SMARCA4‐deficient rhabdoid tumours show intermediate molecular features between SMARCB1‐deficient rhabdoid tumours and small cell carcinomas of the ovary, hypercalcaemic type.
https://doi.org/10.1002/path.5705
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Zschernack Valentina, Jünger Stephanie T., Mynarek Martin, Rutkowski Stefan, Garre Maria Luisa, Ebinger Martin, Neu Marie, Faber Jörg, Erdlenbruch Bernhard, Claviez Alexander, Bielack Stefan, Brozou Triantafyllia, Frühwald Michael C., Dörner Evelyn, Dreschmann Verena, Stock Annika, Solymosi Laszlo, Hench Jürgen, Frank Stephan, Vokuhl Christian, Waha Andreas, Andreiuolo Felipe, Pietsch Torsten.
Supratentorial ependymoma in childhood: more than just RELA or YAP.
https://doi.org/10.1007/s00401-020-02260-5
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van Tilburg Cornelis M., Pfaff Elke, Pajtler Kristian W., Langenberg Karin P. S., Fiesel Petra, Jones Barbara C., Balasubramanian Gnana Prakash, Stark Sebastian, Johann Pascal-David, Blattner-Johnson Mirjam, Schramm Kathrin, Dikow Nicola, Hirsch Steffen, Sutter Christian, Grund Kerstin, von Stackelberg Arend, Kulozik Andreas E., Lissat Andrej, Borkhardt Arndt, Meisel Roland, Reinhardt Dirk, Klusmann Jan-Henning, Fleischhack Gudrun, Tippelt Stephan, von Schweinitz Dietrich, Schmid Irene, Kramm Christof M., von Bueren Andre O., Calaminus Gabriele, Vorwerk Peter, Graf Norbert, Westermann Frank, Fischer Matthias, Eggert Angelika, Burkhardt Birgit, Wossmann Wilhelm, Nathrath Michaela, Hecker-Nolting Stefanie, Frühwald Michael C., Schneider Dominik T., Brecht Ines B, Ketteler Petra, Fulda Simone, Koscielniak Ewa, Meister Michael T., Scheer Monika, Hettmer Simone, Schwab Matthias, Tremmel Roman, Ora Ingrid, Hutter Caroline, Gerber Nicolas U., Lohi Olli, Kazanowska Bernarda, Kattamis Antonis, Filippidou Maria, Goemans Bianca, Zwaan C. Michel, Milde Till, Jager Natalie, Wolf Stephan, Reuss David, Sahm Felix, von Deimling Andreas, Dirksen Uta, Freitag Angelika, Witt Ruth, Lichter Peter, Kopp-Schneider Annette, Jones David T. W., Molenaar Jan J., Capper David, Pfister Stefan M., Witt Olaf.
The pediatric precision oncology INFORM registry: clinical outcome and benefit for patients with very high-evidence targets.
https://doi.org/10.1158/2159-8290.cd-21-0094
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Thomas Christian, Oehl‐Huber Kathrin, Bens Susanne, Soschinski Patrick, Koch Arend, Nemes Karolina, Oyen Florian, Kordes Uwe, Kool Marcel, Frühwald Michael C., Hasselblatt Martin, Siebert Reiner.
Transposable element insertion as a mechanism of SMARCB1 inactivation in atypical teratoid/rhabdoid tumor.
https://doi.org/10.1002/gcc.22954
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2020 |
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Hoffman Lindsey M., Richardson Elizabeth Anne, Ho Ben, Margol Ashley, Reddy Alyssa, Lafay-Cousin Lucie, Chi Susan, Slavc Irene, Judkins Alexander, Hasselblatt Martin, Bourdeaut Franck, Frühwald Michael C., Vibhakar Rajeev, Bouffet Eric, Huang Annie.
Advancing biology-based therapeutic approaches for atypical teratoid rhabdoid tumors.
https://doi.org/10.1093/neuonc/noaa046
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Albert Thomas K, Interlandi Marta, Sill Martin, Graf Monika, Moreno Natalia, Menck Kerstin, Rohlmann Astrid, Melcher Viktoria, Korbanka Sonja, Meyer zu Hörste Gerd, Lautwein Tobias, Frühwald Michael C., Krebs Christian F, Holdhof Dörthe, Schoof Melanie, Bleckmann Annalen, Missler Markus, Dugas Martin, Schüller Ulrich, Jäger Natalie, Pfister Stefan M, Kerl Kornelius.
An extracellular vesicle-related gene expression signature identifies high-risk patients in medulloblastoma.
https://doi.org/10.1093/neuonc/noaa254
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Holdhof Dörthe, Johann Pascal-David, Spohn Michael, Bockmayr Michael, Safaei Sepehr, Joshi Piyush, Masliah-Planchon Julien, Ho Ben, Andrianteranagna Mamy, Bourdeaut Franck, Huang Annie, Kool Marcel, Upadhyaya Santhosh A., Bendel Anne E., Indenbirken Daniela, Foulkes William D., Bush Jonathan W., Creytens David, Kordes Uwe, Frühwald Michael C., Hasselblatt Martin, Schüller Ulrich.
Atypical teratoid/rhabdoid tumors (ATRTs) with SMARCA4 mutation are molecularly distinct from SMARCB1-deficient cases.
https://doi.org/10.1007/s00401-020-02250-7
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Siebel Christian, Würthwein Gudrun, Lanvers-Kaminsky Claudia, André Nicolas, Berthold Frank, Castelli Ilaria, Chastagner Pascal, Doz François, English Martin, Escherich Gabriele, Frühwald Michael C., Graf Norbert, Groll Andreas H., Ruggiero Antonio, Hempel Georg, Boos Joachim.
Can we optimise doxorubicin treatment regimens for children with cancer? Pharmacokinetic simulations and a Delphi consensus procedure.
https://doi.org/10.1186/s40360-020-00417-2
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Thomas Christian, Wefers Annika, Bens Susanne, Nemes Karolina, Agaimy Abbas, Oyen Florian, Vogelgesang Silke, Rodriguez Fausto J., Brett Francesca M., McLendon Roger, Bodi Istvan, Burel-Vandenbos Fanny, Keyvani Kathy, Tippelt Stefan, Poulsen Frantz R., Lipp Eric S., Giannini Caterina, Reifenberger Guido, Kuchelmeister Klaus, Pietsch Torsten, Kordes Uwe, Siebert Reiner, Frühwald Michael C., Johann Pascal-David, Sill Martin, Kool Marcel, Deimling Andreas von, Paulus Werner, Hasselblatt Martin.
Desmoplastic myxoid tumor, SMARCB1-mutant: clinical, histopathological and molecular characterization of a pineal region tumor encountered in adolescents and adults.
https://doi.org/10.1007/s00401-019-02094-w
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Berthold F., Faldum A., Ernst A., Boos J., Dilloo D., Eggert A., Fischer M., Frühwald Michael C., Henze G., Klingebiel T., Kratz C., Kremens B., Krug B., Leuschner I., Schmidt M., Schmidt R., Schumacher-Kuckelkorn R., von Schweinitz D., Schilling F.H., Theissen J., Volland R., Hero B., Simon T..
Extended induction chemotherapy does not improve the outcome for high-risk neuroblastoma patients: results of the randomized open-label GPOH trial NB2004-HR.
https://doi.org/10.1016/j.annonc.2019.11.011
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Waack Katharina, Schneider Markus, Walter Christiane, Creutzig Ursula, Klusmann Jan-Henning, Rasche Mareike, Boztug Heidrun, Jansen Katharina, Escherich Gabriele, Frühwald Michael C., Dworzak Michael, Reinhardt Dirk.
Improved outcome in pediatric AML - the AML-BFM 2012 study [Abstract].
https://doi.org/10.1182/blood-2020-139189
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Melchior Patrick, Dzierma Yvonne, Rübe Christian, Graf Norbert, Kager Leo, Dieckmann Karin, Kroiss Sabine, Hubertus Jochen, Warmann Steven, Schenk Jens-Peter, Leuschner Ivo, Nemes Karolina, Meier Clemens Magnus, Vokuhl Christian, Frühwald Michael C., Furtwängler Rhoikos.
Local stage dependent necessity of radiation therapy in rhabdoid tumors of the kidney (RTK).
https://doi.org/10.1016/j.ijrobp.2020.04.046
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Theruvath Johanna, Sotillo Elena, Mount Christopher W., Graef Claus Moritz, Delaidelli Alberto, Heitzeneder Sabine, Labanieh Louai, Dhingra Shaurya, Leruste Amaury, Majzner Robbie G., Xu Peng, Mueller Sabine, Yecies Derek W., Finetti Martina A., Williamson Daniel, Johann Pascal-David, Kool Marcel, Pfister Stefan, Hasselblatt Martin, Frühwald Michael C., Delattre Olivier, Surdez Didier, Bourdeaut Franck, Puget Stephanie, Zaidi Sakina, Mitra Siddhartha S., Cheshier Samuel, Sorensen Poul H., Monje Michelle, Mackall Crystal L..
Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors.
https://doi.org/10.1038/s41591-020-0821-8
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Melcher Viktoria, Graf Monika, Interlandi Marta, Moreno Natalia, de Faria Flavia W., Kim Su Na, Kastrati Dennis, Korbanka Sonja, Alfert Amelie, Gerß Joachim, Meyer zu Hörste Gerd, Hartmann Wolfgang, Frühwald Michael C., Dugas Martin, Schüller Ulrich, Hasselblatt Martin, Albert Thomas K., Kerl Kornelius.
Macrophage-tumor cell interaction promotes ATRT progression and chemoresistance.
https://doi.org/10.1007/s00401-019-02116-7
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Kuwahara Yasumichi, Iehara Tomoko, Ichise Eisuke, Katsumi Yoshiki, Ouchi Kazutaka, Tsuchiya Kunihiko, Miyachi Mitsuru, Konichi Eiichi, Sasajima Hiroyasu, Nakamura Satoaki, Fumino Shigehisa, Tajiri Tatsuro, Johann Pascal-David, Frühwald Michael C., Yoshida Tatsushi, Okuda Tsukasa, Hosoi Hajime.
Novel two MRT cell lines established from multiple sites of a synchronous MRT patient.
https://doi.org/10.21873/anticanres.14636
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Kuhlen Michaela, Frühwald Michael C., Dunstheimer Désirée P. A., Vorwerk Peter, Redlich Antje.
Revisiting the genotype‐phenotype correlation in children with medullary thyroid carcinoma: a report from the GPOH‐MET registry.
https://doi.org/10.1002/pbc.28171
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Kunz Joachim B., Lobitz Stephan, Grosse Regine, Oevermann Lena, Hakimeh Dani, Jarisch Andrea, Cario Holger, Beier Rita, Schenk Daniela, Schneider Dominik, Groß‐Wieltsch Ute, Prokop Aram, Heine Sabine, Khurana Claudia, Erlacher Miriam, Dürken Matthias, Linke Christina, Frühwald Michael C., Corbacioglu Selim, Claviez Alexander, Metzler Markus, Ebinger Martin, Full Hermann, Wiesel Thomas, Eberl Wolfgang, Reinhard Harald, Tagliaferri Laura, Allard Pierre, Karapanagiotou‐Schenkel Irini, Rother Lisa‐Marie, Beck Dorothea, Le Cornet Lucian, Kulozik Andreas E..
Sickle cell disease in Germany: results from a national registry.
https://doi.org/10.1002/pbc.28130
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Hasselblatt M., Thomas C., Nemes K., Monoranu C.‐M., Riemenschneider M. J., Koch A., Sumerauer D., Hauser P., Paulus W., Johann Pascal-David, Kool M., Frühwald Michael C..
Tyrosinase immunohistochemistry can be employed for the diagnosis of atypical teratoid/rhabdoid tumours of the tyrosinase subgroup (ATRT‐TYR).
https://doi.org/10.1111/nan.12560
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2019 |
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Frühwald Michael C., Hasselblatt Martin, Nemes Karolina, Bens Susanne, Steinbügl Mona, Johann Pascal-David, Kerl Kornelius, Hauser Peter, Quiroga Eduardo, Solano-Paez Palma, Biassoni Veronica, Gil-da-Costa Maria Joao, Perek-Polnik Martha, van de Wetering Marianne, Sumerauer David, Pears Jane, Stabell Niklas, Holm Stefan, Hengartner Heinz, Gerber Nicolas U., Grotzer Michael, Boos Joachim, Ebinger Martin, Tippelt Stefan, Paulus Werner, Furtwängler Rhoikos, Hernáiz-Driever Pablo, Reinhard Harald, Rutkowski Stefan, Schlegel Paul-Gerhardt, Schmid Irene, Kortmann Rolf-Dieter, Timmermann Beate, Warmuth-Metz Monika, Kordes Uwe, Gerss Joachim, Nysom Karsten, Schneppenheim Reinhard, Siebert Reiner, Kool Marcel, Graf Norbert.
Age and DNA methylation subgroup as potential independent risk factors for treatment stratification in children with atypical teratoid/rhabdoid tumors.
https://doi.org/10.1093/neuonc/noz244
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Rizzari Carmelo, Lanvers-Kaminsky Claudia, Valsecchi Maria Grazia, Ballerini Andrea, Matteo Cristina, Gerss Joachim, Wuerthwein Gudrun, Silvestri Daniela, Colombini Antonella, Conter Valentino, Biondi Andrea, Schrappe Martin, Moericke Anja, Zimmermann Martin, von Stackelberg Arend, Linderkamp Christin, Frühwald Michael C., Legien Sabine, Attarbaschi Andishe, Reismüller Bettina, Kasper David, Smisek Petr, Stary Jan, Vinti Luciana, Barisone Elena, Parasole Rosanna, Micalizzi Concetta, Zucchetti Massimo, Boos Joachim.
Asparagine levels in the cerebrospinal fluid of children with acute lymphoblastic leukemia treated with pegylated-asparaginase in the induction phase of the AIEOP-BFM ALL 2009 study.
https://doi.org/10.3324/haematol.2018.206433
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Pfaff Elke, El Damaty Ahmed, Balasubramanian Gnana Prakash, Blattner-Johnson Mirjam, Worst Barbara C., Stark Sebastian, Witt Hendrik, Pajtler Kristian W., van Tilburg Cornelis M., Witt Ruth, Milde Till, Jakobs Martin, Fiesel Petra, Frühwald Michael C., Hernáiz Driever Pablo, Thomale Ulrich W., Schuhmann Martin U., Metzler Markus, Bochennek Konrad, Simon Thorsten, Dürken Matthias, Karremann Michael, Knirsch Stephanie, Ebinger Martin, von Bueren André O., Pietsch Torsten, Herold-Mende Christel, Reuss David E., Kiening Karl, Lichter Peter, Eggert Angelika, Kramm Christof M., Pfister Stefan M., Jones David T.W., Bächli Heidi, Witt Olaf.
Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience.
https://doi.org/10.1016/j.ejca.2019.03.019
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Erkek Serap, Johann Pascal-David, Finetti Martina A., Drosos Yiannis, Chou Hsien-Chao, Zapatka Marc, Sturm Dominik, Jones David T. W., Korshunov Andrey, Rhyzova Marina, Wolf Stephan, Mallm Jan-Philipp, Beck Katja, Witt Olaf, Kulozik Andreas E., Frühwald Michael C., Northcott Paul A., Korbel Jan O., Lichter Peter, Eils Roland, Gajjar Amar, Roberts Charles W. M., Williamson Daniel, Hasselblatt Martin, Chavez Lukas, Pfister Stefan M., Kool Marcel.
Comprehensive analysis of chromatin states in atypical teratoid/rhabdoid tumor identifies diverging roles for SWI/SNF and polycomb in gene regulation.
https://doi.org/10.1016/j.ccell.2018.11.014
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Tegeder Isabel, Thiel Katharina, Erkek Serap, Johann Pascal-David, Berlandi Johannes, Thatikonda Venu, Frühwald Michael C., Kool Marcel, Jeibmann Astrid, Hasselblatt Martin.
Functional relevance of genes predicted to be affected by epigenetic alterations in atypical teratoid/rhabdoid tumors.
https://doi.org/10.1007/s11060-018-03018-6
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Desch Ann-Kathrin, Hartung Kristin, Botzen Ante, Brobeil Alexander, Rummel Mathias, Kurch Lars, Georgi Thomas, Jox Theresa, Bielack Stefan, Burdach Stefan, Classen Carl Friedrich, Claviez Alexander, Debatin Klaus-Michael, Ebinger Martin, Eggert Angelika, Faber Jörg, Flotho Christian, Frühwald Michael C., Graf Norbert, Jorch Norbert, Kontny Udo, Kramm Christof, Kulozik Andreas, Kühr Joachim, Sykora Karl-Walter, Metzler Markus, Müller Hermann L., Nathrath Michaela, Nüßlein Thomas, Paulussen Michael, Pekrun Arnulf, Reinhardt Dirk, Reinhard Harald, Rössig Claudia, Sauerbrey Axel, Schlegel Paul-Gerhardt, Schneider Dominik T., Scheurlen Wolfram, Schweigerer Lothar, Simon Thorsten, Suttorp Meinolf, Vorwerk Peter, Schmitz Roland, Kluge Regine, Mauz-Körholz Christine, Körholz Dieter, Gattenlöhner Stefan, Bräuninger Andreas.
Genotyping circulating tumor DNA of pediatric Hodgkin lymphoma.
https://doi.org/10.1038/s41375-019-0541-6
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Kuhlen Michaela, Wieczorek Dagmar, Siebert Reiner, Frühwald Michael C..
How I approach hereditary cancer predisposition in a child with cancer.
https://doi.org/10.1002/pbc.27916
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Chun Hye-Jung E., Johann Pascal-David, Milne Katy, Zapatka Marc, Buellesbach Annette, Ishaque Naveed, Iskar Murat, Erkek Serap, Wei Lisa, Tessier-Cloutier Basile, Lever Jake, Titmuss Emma, Topham James T., Bowlby Reanne, Chuah Eric, Mungall Karen L., Ma Yussanne, Mungall Andrew J., Moore Richard A., Taylor Michael D., Gerhard Daniela S., Jones Steven J. M., Korshunov Andrey, Gessler Manfred, Kerl Kornelius, Hasselblatt Martin, Frühwald Michael C., Perlman Elizabeth J., Nelson Brad H., Pfister Stefan M., Marra Marco A., Kool Marcel.
Identification and analyses of extra-cranial and cranial rhabdoid tumor molecular subgroups reveal tumors with cytotoxic T cell infiltration.
https://doi.org/10.1016/j.celrep.2019.10.013
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Ho Ben, Johann Pascal-David, Grabovska Yura, De Dieu Andrianteranagna Mamy Jean, Yao Fupan, Frühwald Michael C., Hasselblatt Martin, Bourdeaut Franck, Williamson Daniel, Huang Annie, Kool Marcel.
Molecular subgrouping of atypical teratoid/rhabdoid tumors: a reinvestigation and current consensus.
https://doi.org/10.1093/neuonc/noz235
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Zierk Jakob, Hirschmann Johannes, Toddenroth Dennis, Arzideh Farhad, Haeckel Rainer, Bertram Alexander, Cario Holger, Frühwald Michael C., Groß Hans-Jürgen, Groening Arndt, Grützner Stefanie, Gscheidmeier Thomas, Hoff Torsten, Hoffmann Reinhard, Klauke Rainer, Krebs Alexander, Lichtinghagen Ralf, Mühlenbrock-Lenter Sabine, Neumann Michael, Nöllke Peter, Niemeyer Charlotte M., Razum Oliver, Ruf Hans-Georg, Steigerwald Udo, Streichert Thomas, Torge Antje, Rascher Wolfgang, Prokosch Hans-Ulrich, Rauh Manfred, Metzler Markus.
Next-generation reference intervals for pediatric hematology.
https://doi.org/10.1515/cclm-2018-1236
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van Tilburg Cornelis M., Milde Till, Witt Ruth, Ecker Jonas, Hielscher Thomas, Seitz Angelika, Schenk Jens-Peter, Buhl Juliane L., Riehl Dennis, Frühwald Michael C., Pekrun Arnulf, Rossig Claudia, Wieland Regina, Flotho Christian, Kordes Uwe, Gruhn Bernd, Simon Thorsten, Linderkamp Christin, Sahm Felix, Taylor Lenka, Freitag Angelika, Burhenne Jürgen, Foerster Kathrin I., Meid Andreas D., Pfister Stefan M., Karapanagiotou-Schenkel Irini, Witt Olaf.
Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia.
https://doi.org/10.1186/s13148-019-0775-1
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Benesch Martin, Nemes Karolina, Neumayer Petra, Hasselblatt Martin, Timmermann Beate, Bison Brigitte, Ebetsberger‐Dachs Georg, Bourdeaut Franck, Dufour Christelle, Biassoni Veronica, Morales La Madrid Andrés, Entz‐Werle Natacha, Laithier Véronique, Quehenberger Franz, Weis Serge, Sumerauer David, Siebert Reiner, Bens Susanne, Schneppenheim Reinhard, Kool Marcel, Modena Piergiorgio, Fouyssac Fanny, Frühwald Michael C..
Spinal cord atypical teratoid/rhabdoid tumors in children: clinical, genetic, and outcome characteristics in a representative European cohort.
https://doi.org/10.1002/pbc.28022
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Thomas Christian, Knerlich-Lukoschus Friederike, Reinhard Harald, Johann Pascal-David, Sturm Dominik, Sahm Felix, Bens Susanne, Vogt Julia, Nemes Karolina, Oyen Florian, Kordes Uwe, Siebert Reiner, Schneppenheim Reinhard, Messing-Jünger Martina, Pietsch Torsten, von Deimling Andreas, Paulus Werner, Pfister Stefan M., Kool Marcel, Frühwald Michael C., Hasselblatt Martin.
Two molecularly distinct atypical teratoid/rhabdoid tumors (or tumor components) occurring in an infant with rhabdoid tumor predisposition syndrome 1.
https://doi.org/10.1007/s00401-019-02001-3
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Sykora Karl-Walter, Metzger Jochen, Körholz Dieter, Frühwald Michael C., Strauss Gabriele, Jorch Norbert, Zlocha Jozef, Wiesel Thomas, Sauerbrey Axel, Streiter Monika, Furtwaengler Rhoikos, Cario Gunnar, Simon Thorsten, Christiansen Holger, Vorwerk Peter, Wawer Angela, Scheurlen Wolfram, Müller Hermann, Bielack Stefan, Ebinger Martin, Debatin Klaus-Michael, Andres Oliver, Mauz-Körholz Christine, Troeger Anja, Schneider Dominik, Weissinger Eva M.
Urine proteomic analysis reveals disease-specific patterns in pediatric patients with classical Hodgkin's Disease(HD): an Addon study to the Euronet-PHL-C2 Trial.
https://doi.org/10.1182/blood-2019-125611
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2018 |
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Frühwald Michael C., Hasselblatt Martin, Schneppenheim Reinhard, Nemes Karolina, Bens Susanne, Johan Pascal, Hauser Peter, Quiroga Eduardo, Solano-Paez Palma, Biassoni Veronica, Gil-da-Costa Maria Joao, Perek-Polnik Martha, van de Wetering Marianne, Ebinger Martin, Fleischhack Gudrun, Furtwaengler Rhoikos, Hernaiz-Driever Pablo, Reinhard Harald, Rukowski Stefan, Schlegel Paul-Gerhardt, Schmid Irene, Timmermann Beate, Kordes Uwe, Gerss Joachim, Kerl Kornelius, Nysom Karsten, Siebert Reiner, Kool Marcel, Graf Norbert.
ATRT-06. Clinical and molecular risk factors in children with atypical teratoid/rhabdoid tumor (AT/RT): evicence from the EU-Rhab registry.
https://doi.org/10.1093/neuonc/noy059.005
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Galarza Natalia Moreno, Holdhof Dörthe, Interlandi Marta, Melcher Viktoria, Graf Monika, Kastrati Dennis, Meisterernst Michael, Johann Pascal-David, Kool Marcel, Frühwald Michael C., Schüller Ulrich, Kerl Kornelius.
ATRT-07. Murine Sox2-positive early precursor cells give rise to rhabdoid tumors with features of the human ATRT-MYC group.
https://doi.org/10.1093/neuonc/noy059.006
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Benesch Martin, Neumayer Petra, Nemes Karolina, Pietsch Torsten, Timmermann Beate, Bison Brigitte, Warmuth-Metz Monika, Driever Pablo Hernáiz, Ebetsberger-Dachs Georg, Bourdeaut Franck, Dufour Christelle, Fouyssac Fanny, Hasselblatt Martin, Biassoni Veronica, La Madrid Andrés Morales, Entz-Werle Natacha, Laithier Véronique, Quehenberger Franz, Frühwald Michael C..
ATRT-15. Spinal cord atypical Teratoid/Rhabdoid tumors (AT/RT) in children: results of a European retrospective analysis under the auspices of the EU-RHAB study group.
https://doi.org/10.1093/neuonc/noy059.013
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Nemes Karolina, Clément Nathalie, Kachanov Denis, Bens Susanne, Shamanskaya Tatyana, Varfolomeeva Svetlana, Kerl Kornelius, Abbink Floor, Ebinger Martin, Tippelt Stephan, Graf Norbert, Hasselblatt Martin, Hernáiz-Driever Pablo, Gil-Da-Costa Maria João, Klingebiel Thomas, Kortmann Rolf-Dieter, Pears Jane, Schlegel Paul-Gerhardt, Andre Nicolas, Bertozzi Anne-Isabelle, Corradini Nadège, Dufour Christelle, Fouyssac Fanny, Leblond Pierre, Delattre Olivier, Masliah-Planchon Julien, Simon Thorsten, Timmermann Beate, Witt Olaf, Schneppenheim Reinhard, Gerss Joachim, Siebert Reiner, Furtwängler Rhoikos, Bourdeaut Franck, Frühwald Michael C..
ATRT-16. Congenital Rhabdiod tumors as a major clinical challenge: a collaborative European effort.
https://doi.org/10.1093/neuonc/noy059.014
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Nemes Karolina, Hasselblatt Martin, Bens Susanne, Erdreich-Epstein Anat, Biegel Jaclyn, Khatib Ziad, Liaugaudiene Olga, Sadeghipour Alireza, Ebetsberger-Dachs Georg, Lemmer Andreas, Khurana Claudia, von der Weid Nicolas, Schmid Irene, Mora Jaume, Marques Carmen Hernandez, Pears Jane, Timmermann Beate, Kodes Uwe, Gerss Joachim, Furtwängler Rhoikos, Siebert Reiner, Frühwald Michael C..
ATRT-17. Assisted reproductive technologies and the development of malignant Rhabdoid tumours.
https://doi.org/10.1093/neuonc/noy059.015
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Holsten Till, Alawi Malik, Spohn Michael, Hasselblatt Martin, Haberler Christine, Antonelli Manila, Koch Arend, Kool Marcel, Frühwald Michael C., Schüller Ulrich.
ATRT-21. Comparative integrative analysis of primary and relapsed atypical Teratoid/Rhabdoid tumors (AT/RTs).
https://doi.org/10.1093/neuonc/noy059.019
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Capper D., Jones D. T. W., Sill M., Hovestadt V., Schrimpf D., Sturm D., Koelsche C., Sahm F., Chavez L., Reuss D. E., Kratz A., Wefers A. K., Huang K., Pajtler K. W., Schweizer L., Stichel D., Olar A., Engel N. W., Lindenberg K., Harter P. N., Braczynski A. K., Plate K. H., Dohmen H., Garvalov B. K., Coras R., Hölsken A., Hewer E., Bewerunge-Hudler M., Schick M., Fischer R., Beschorner R., Schittenhelm J., Staszewski O., Wani K., Varlet P., Pages M., Temming P., Lohmann D., Selt F., Witt H., Milde T., Witt O., Aronica E., Giangaspero F., Rushing E., Scheurlen W., Geisenberger C., Rodriguez F. J., Becker A., Preusser M., Haberler C., Bjerkvig R., Cryan J., Farrell M., Deckert M., Hench J., Frank S., Serrano J., Kannan K., Tsirigos A., Brück W., Hofer S., Brehmer S., Seiz-Rosenhagen M., Hänggi D., Hans V., Rozsnoki S., Hansford J. R., Kohlhof P., Kristensen B. W., Lechner M., Lopes B., Mawrin C., Ketter R., Kulozik A., Khatib Z., Heppner F., Koch A., Jouvet A., Keohane C., Mühleisen H., Mueller W., Pohl U., Prinz M., Benner A., Zapatka M., Gottardo N. G., Driever P. H., Kramm C. M., Müller H. L., Rutkowski S., von Hoff K., Frühwald Michael C., Gnekow Astrid K., Fleischhack G., Trippelt S., Calaminus G., Monoranu C.-M., Perry A., Jones C., Jacques T. S., Radlwimmer B., Gessi M., Pietsch T., Schramm J., Schackert G., Westphal M., Reifenberger G., Wesseling P., Weller M., Collins V. P., Blümcke I., Bendszus M., Debus J., Huang A., Jabado N., Northcott P. A., Paulus W., Gajjar A., Robinson G. W., Taylor M. D., Jaunmuktane Z., Ryzhova M., Platten M., Unterberg A., Wick W., Karajannis M. A., Mittelbronn M., Acker T., Hartmann C., Aldape K., Schüller U., Buslei R., Lichter P., Kool M., Herold-Mende C., Ellison D. W., Hasselblatt M., Snuderl M., Brandner S., Korshunov A., Deimling Andreas von, Pfister S. M..
DNA methylation-based classification of central nervous system tumours.
https://doi.org/10.1038/nature26000
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Nemes Karolina, Frühwald Michael C..
Emerging therapeutic targets for the treatment of malignant rhabdoid tumors.
https://doi.org/10.1080/14728222.2018.1451839
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Holsten Till, Bens Susanne, Oyen Florian, Nemes Karolina, Hasselblatt Martin, Kordes Uwe, Siebert Reiner, Frühwald Michael C., Schneppenheim Reinhard, Schüller Ulrich.
Germline variants in SMARCB1 and other members of the BAF chromatin-remodeling complex across human disease entities: a meta-analysis.
https://doi.org/10.1038/s41431-018-0143-1
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Furtwängler R., Kager L., Melchior P., Rübe C., Ebinger M., Nourkami-Tutdibi N., Niggli F., Warmann S., Hubertus J., Amman G., Leuschner I., Vokuhl C., Graf N., Frühwald Michael C..
High‐dose treatment for malignant rhabdoid tumor of the kidney: no evidence for improved survival - the Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH) experience.
https://doi.org/10.1002/pbc.26746
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Marcu Ana, Trautwein Nico, Stevanovic Stefan, Johann Pascal-David, Technau Antje, Lager Johanna, Monoranu Camelia-Maria, Henkel Lisa, Krauß Jürgen, Ebinger Martin, Schuhmann Martin, Thomale Ulrich, Pietsch Torsten, Wölfl Matthias, Schlegel Paul Gerhardt, Frühwald Michael C., Oyen Florian, Reisner Yair, Rammensee Hans-Georg, Eyrich Matthias.
IMMU-28. Deciphering the AT/RT ligandome.
https://doi.org/10.1093/neuonc/noy059.344
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Behnert Astrid, Auber Bernd, Steinemann Doris, Frühwald Michael C., Huisinga Carolin, Hussein Kais, Kratz Christian, Ripperger Tim.
KBG syndrome patient due to 16q24.3 microdeletion presenting with a paratesticular rhabdoid tumor: coincidence or cancer predisposition?.
https://doi.org/10.1002/ajmg.a.38724
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Schimmel Mareike, Frühwald Michael C., Bien C. G..
Limbic encephalitis with LGI1 antibodies in a 14-year-old boy.
https://doi.org/10.1016/j.ejpn.2017.08.004
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Tilburg Cornelis Martinus van, Milde Till, Witt Ruth, Ecker Jonas, Seitz Angelika, Schenk Jens-Peter, Frühwald Michael C., Pekrun Arnulf, Rössig Claudia, Wieland Regina, Flotho Christian, Kordes Uwe, Gruhn Bernd, Simon Thorsten, Linderkamp Christin, Taylor Lenka, Burhenne Juergen, Pfister Stefan M., Karapanagiotou-Schenkel Irini, Witt Olaf.
Phase 1/2 intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia.
https://doi.org/10.1200/jco.2018.36.15_suppl.10535
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Johann Pascal-David, Bens S., Oyen F., Wagener R., Giannini C., Perry A., Raisanen J. M., Reis G. F., Nobusawa S., Arita K., Felsberg J., Reifenberger G., Agaimy A., Buslei R., Capper D., Pfister S. M., Schneppenheim R., Siebert R., Frühwald Michael C., Paulus W., Kool M., Hasselblatt M..
Sellar region atypical teratoid/rhabdoid tumors (ATRT) in adults display DNA methylation profiles of the ATRT-MYC subgroup.
https://doi.org/10.1097/PAS.0000000000001023
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Nemes K., Clement N., Kachanov D., Bens S., Hasselblatt M., Timmermann B., Schneppenheim R., Gerss J., Siebert R., Furtwängler R., Bourdeaut F., Frühwald Michael C..
The extraordinary challenge of treating patients with congenital rhabdoid tumors-a collaborative European effort.
https://doi.org/10.1002/pbc.26999
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Gröbner Susanne N., Worst Barbara C., Weischenfeldt Joachim, Buchhalter Ivo, Kleinheinz Kortine, Rudneva Vasilisa A., Johann Pascal-David, Balasubramanian Gnana Prakash, Segura-Wang Maia, Brabetz Sebastian, Bender Sebastian, Hutter Barbara, Sturm Dominik, Pfaff Elke, Hübschmann Daniel, Zipprich Gideon, Heinold Michael, Eils Jürgen, Lawerenz Christian, Erkek Serap, Lambo Sander, Waszak Sebastian, Blattmann Claudia, Borkhardt Arndt, Kuhlen Michaela, Eggert Angelika, Fulda Simone, Gessler Manfred, Wegert Jenny, Kappler Roland, Baumhoer Daniel, Burdach Stefan, Kirschner-Schwabe Renate, Kontny Udo, Kulozik Andreas E., Lohmann Dietmar, Hettmer Simone, Eckert Cornelia, Bielack Stefan, Nathrath Michaela, Niemeyer Charlotte, Richter Günther H., Schulte Johannes, Siebert Reiner, Westermann Frank, Molenaar Jan J., Vassal Gilles, Witt Hendrik, Burkhardt Birgit, Kratz Christian P., Witt Olaf, van Tilburg Cornelis M., Kramm Christof M., Fleischhack Gudrun, Dirksen Uta, Rutkowski Stefan, Frühwald Michael C., von Hoff Katja, Wolf Stephan, Klingebiel Thomas, Koscielniak Ewa, Landgraf Pablo, Koster Jan, Resnick Adam C., Zhang Jinghui, Liu Yanling, Zhou Xin, Waanders Angela J., Zwijnenburg Danny A., Raman Pichai, Brors Benedikt, Weber Ursula D., Northcott Paul A., Pajtler Kristian W., Kool Marcel, Piro Rosario M., Korbel Jan O., Schlesner Matthias, Eils Roland, Jones David T. W., Lichter Peter, Chavez Lukas, Zapatka Marc, Pfister Stefan M..
The landscape of genomic alterations across childhood cancers.
https://doi.org/10.1038/nature25480
PDF | BibTeX | RIS | DOI Correction (2018): Nature 559, E10, DOI: 10.1038/s41586-018-0167-2 |
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Fleischhack G., Rutkowski S., Pfister S., Pietsch T., Tippelt S., Warmuth-Metz M., Bison Brigitte, van Velthoven-Wurster V., Messing-Jünger M., Kortmann R.-D., Timmermann B., Slavc I., Witt O., Gnekow Astrid K., Hernáiz Driever P., Kramm C., Benesch M., Frühwald Michael C., Hasselblatt M., Müller H. L., Sörensen N., Kordes U. R., Calaminus G..
ZNS-Tumoren.
https://doi.org/10.1007/978-3-662-43686-8_23
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2017 |
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Bozzai B., Hasselblatt M., Turanyi E., Frühwald Michael C., Siebert R., Bens S., Schneppenheim R., Kool M., Stelczer G., Hortobagyi T., Hauser P..
Atypical teratoid/rhabdoid tumor arising in a malignant glioma.
https://doi.org/10.1002/pbc.26173
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Krämer Katja, Moreno Natalia, Frühwald Michael C., Kerl Kornelius.
BRD9 inhibition, alone or in combination with cytostatic compounds as a therapeutic approach in rhabdoid tumors.
https://doi.org/10.3390/ijms18071537
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Johann Pascal-David, Hovestadt Volker, Thomas Christian, Jeibmann Astrid, Heß Katharina, Bens Susanne, Oyen Florian, Hawkins Cynthia, Pierson Christopher R., Aldape Kenneth, Kim Sang-Pyo, Widing Eva, Sumerauer David, Hauser Péter, van Landeghem Frank, Ryzhova Marina, Korshunov Andrey, Capper David, Jones David T.W., Pfister Stefan M., Schneppenheim Reinhard, Siebert Reiner, Paulus Werner, Frühwald Michael C., Kool Marcel, Hasselblatt Martin.
Cribriform neuroepithelial tumor: molecular characterization of a SMARCB1-deficient non-rhabdoid tumor with favorable long-term outcome.
https://doi.org/10.1111/bpa.12413
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Peters S., Christiaens M., Schulz S., Frisch S., Kramer P. H., Blase C., Frühwald Michael C., Timmermann B..
EP-1382: Feasibility of proton therapy with concomitant chemotherapy for atypical teratoid rhabdoid tumors.
https://doi.org/10.1016/s0167-8140(17)31817-0
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Holsten Till, Hasselblatt Martin, Kordes Uwe, Siebert Reiner, Schneppenheim Reinhard, Frühwald Michael C., Schüller Ulrich.
GENE-02: germline mutations within the SWI/SNF complex predict patients' age of onset and type of disease.
https://doi.org/10.1093/neuonc/nox083.073
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Holsten Till, Schuster Tobias, Grabhorn Enke, Hero Barbara, Frühwald Michael C..
Liver transplantation as a potentially lifesaving measure in neuroblastoma stage 4S.
https://doi.org/10.1080/08880018.2016.1266535
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Storck Simone, Kennedy Alyssa L., Marcus Karen J., Teot Lisa, Vaughn Jennifer, Gnekow Astrid K., Märkl Bruno, Leuschner Ivo, DuBois Steven G., French Christopher A., Frühwald Michael C..
Pediatric NUT-midline carcinoma: therapeutic success employing a sarcoma based multimodal approach.
https://doi.org/10.1080/08880018.2017.1363839
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Zierk Jakob, Arzideh Farhad, Haeckel Rainer, Cario Holger, Frühwald Michael C., Groß Hans-Jürgen, Gscheidmeier Thomas, Hoffmann Reinhard, Krebs Alexander, Lichtinghagen Ralf, Neumann Michael, Ruf Hans-Georg, Steigerwald Udo, Streichert Thomas, Rascher Wolfgang, Metzler Markus, Rauh Manfred.
Pediatric reference intervals for alkaline phosphatase.
https://doi.org/10.1515/cclm-2016-0318
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Hasselblatt Martin, Johann Pascal-David, Kool Marcel, Frühwald Michael C..
Reduced histone H3 K27 trimethylation is encountered in about 50% of atypical teratoid/rhabdoid tumors (AT/RT) but is not associated with molecular subgroup status and outcome.
https://doi.org/10.1007/s00401-017-1766-y
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Jeibmann Astrid, Schulz Jacqueline, Eikmeier Kristin, Johann Pascal-David, Thiel Katharina, Tegeder Isabel, Ambrée Oliver, Frühwald Michael C., Pfister Stefan M., Kool Marcel, Paulus Werner, Hasselblatt Martin.
SMAD dependent signaling plays a detrimental role in a fly model of SMARCB1-deficiency and the biology of atypical teratoid/rhabdoid tumors.
https://doi.org/10.1007/s11060-016-2326-3
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Bens Susanne, Kehrer-Sawatzki Hildegard, Hasselblatt Martin, Frühwald Michael C., Siebert Reiner.
SWI/SNF-Komplex-assoziierte Tumordispositions-Syndrome.
https://doi.org/10.1007/s11825-017-0160-4
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Holsten T., Hasselblatt M., Kordes U., Siebert R., Schneppenheim R., Frühwald Michael C., Schüller U..
Updated dataset of germline mutations within the SWI/SNF complex predicting age of tumor onset and type of disease.
https://doi.org/10.1055/s-0037-1602213
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2016 |
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Kohlhof Hella, Wulff Tanja, Vitt Daniel, Frühwald Michael C..
AT-04: towards an epigenetic therapy for rhabdoid tumors - in vitro results for the epigentic modulators resminostat and 4SC-202.
https://doi.org/10.1093/neuonc/now065.03
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Seeringer Angela, Veal Gareth, Neumayer Petra, Frühwald Michael C..
AT-05: veno-occlusive disease (vod) is a notable side effect of therapy in infants with rhabdoid tumors.
https://doi.org/10.1093/neuonc/now065.04
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Frühwald Michael C., Kachanov Denis, Zlatic Monica, Clement Nathalie, Shamaskaya Tatyana, Varfolomeeva Svetlana, Schneppenheim Reinhard, Siebert Reiner, Gerss Joachim, Hasselblatt Martin, Bourdeaut Franck.
AT-06: the extraordinary challenge of treating patients with congenital rhabdoid tumors - data from France, Russia and the EU-RHAB Registry.
https://doi.org/10.1093/neuonc/now065.05
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Thomas Christian, Hovestadt Volker, Schrimpf Daniel, Johann Pascal-David, Bens Susanne, Oyen Florian, Vogel Hannes, Giangaspero Felice, Antonelli Manila, Riemenschneider Markus, Bernardo Marie Christine, Giannini Caterina, Din Nasir Ud, Perry Arie, Keyvani Kathy, van Landeghem Frank, Sumerauer David, Hauser Peter, Capper David, Korshunov Andrey, Jones David T. W., Pfister Stefan, Schneppenheim Reinhard, Siebert Reiner, Frühwald Michael C., Kool Marcel, Hasselblatt Martin.
AT-10: atypical teratoid rhabdoid tumors and poorly differentiated chordomas: distinct molecular entities with SMARCB1/INI1 loss and dismal prognosis.
https://doi.org/10.1093/neuonc/now065.09
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Hasselblatt Martin, Thomas Christian, Heß Katharina, Hovestadt Volker, Johann Pascal-David, Bens Susanne, Oyen Florian, Hawkins Cynthia, Pierson Christopher R., Aldape Kenneth, Kim Sang Pyo, Widing Eva, Capper David, Jones David T.W., Pfister Stefan M., Schneppenheim Reinhard, Siebert Reiner, Paulus Werner, Frühwald Michael C., Kool Marcel.
AT-11: cribriform neuroepithelial tumor (crinet): molecular characterization of a SMARCB1-deficient non-rhabdoid tumor with favorable long-term outcome.
https://doi.org/10.1093/neuonc/now065.10
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Frühwald Michael C., Nemes Karolina, Schlegel Paul-Gerhard, Schmid Irene, Gerss Joachim, Schneppenheim Reinhard, Siebert Reiner, Kerl Kornelius, Hernaiz-Driever Pablo, Kool Marcel, Hasselblatt Martin, Nysom Karsten.
AT-13: the EU-Rhab experience: clinical, genetic and survival data define a standard of care and are the basics for clinical trials.
https://doi.org/10.1093/neuonc/now065.12
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Lolith G.R., Frisch S., Schulze Schleithoff Stefanie, Christiaens Melissa, Peters Shola, Plaude Sandija, Blase C., Frühwald Michael C., Fleischhack Gudrun, Tippelt Stephan, Timmermann B..
Atypical teratoid/rhabdoid tumor treated by proton beam therapy: initial experience at the West German proton therapy center Essen.
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Frühwald Michael C., Biegel Jaclyn A., Bourdeaut Franck, Roberts Charles W.M., Chi Susan N..
Atypical teratoid/rhabdoid tumors - current concepts, advances in biology, and potential future therapies.
https://doi.org/10.1093/neuonc/nov264
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Johann Pascal-David, Erkek Serap, Zapatka Marc, Kerl Kornelius, Buchhalter Ivo, Hovestadt Volker, Jones David T. W., Sturm Dominik, Hermann Carl, Segura Wang Maia, Korshunov Andrey, Rhyzova Marina, Gröbner Susanne, Brabetz Sebastian, Chavez Lukas, Bens Susanne, Gröschel Stefan, Kratochwil Fabian, Wittmann Andrea, Sieber Laura, Geörg Christina, Wolf Stefan, Beck Katja, Oyen Florian, Capper David, van Sluis Peter, Volckmann Richard, Koster Jan, Versteeg Rogier, Deimling Andreas von, Milde Till, Witt Olaf, Kulozik Andreas E., Ebinger Martin, Shalaby Tarek, Grotzer Michael, Sumerauer David, Zamecnik Josef, Mora Jaume, Jabado Nada, Taylor Michael D., Huang Annie, Aronica Eleonora, Bertoni Anna, Radlwimmer Bernhard, Pietsch Torsten, Schüller Ulrich, Schneppenheim Reinhard, Northcott Paul A., Korbel Jan O., Siebert Reiner, Frühwald Michael C., Lichter Peter, Eils Roland, Gajjar Amar, Hasselblatt Martin, Pfister Stefan M., Kool Marcel.
Atypical teratoid/rhabdoid tumors are comprised of three epigenetic subgroups with distinct enhancer landscapes.
https://doi.org/10.1016/j.ccell.2016.02.001
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Erkek Serap, Johann Pascal-David, Kerl Kornelius, Finetti Martina, Zapatka Marc, Frühwald Michael C., Chavez Lukas, Gajjar Amar, Williamson Daniel, Hasselblatt Martin, Pfister Stefan M., Kool Marcel.
GENT-28: the epigenetic landscape of atypical teratoid/rhabdoid tumors reveals a repressed methylome and epigenetic switches at SMARCB1 binding sites.
https://doi.org/10.1093/neuonc/now212.334
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Neuner Bruno, Mackensen Sylvia von, Holzhauer Susanne, Funk Stephanie, Klamroth Robert, Kurnik Karin, Krümpel Anne, Halimeh Susan, Reinke Sarah, Frühwald Michael C., Nowak-Göttl Ulrike.
Health-related quality of life in children and adolescents with hereditary bleeding disorders and in children and adolescents with stroke: cross-sectional comparison to siblings and peers.
https://doi.org/10.1155/2016/1579428
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Juhnke B.-Ole, Bison Brigitte, Frühwald Michael C., Kortmann Rolf-D., Witt Hendrik, Rutkowski Stefan.
Hirntumoren im Kindes- und Jugendalter.
https://doi.org/10.1007/s00761-016-0127-0
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van Gool Stefaan W., Holm Stefan, Rachor Johannes, Adamson Lars, Technau Antje, Maass Eberhard, Frühwald Michael C., Schlegel Paul G., Eyrich Matthias.
Immunotherapy in atypical teratoid-rhabdoid tumors: data from a survey of the HGG-Immuno Group.
https://doi.org/10.1016/j.jcyt.2016.06.004
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Bartelheim Kerstin, Nemes Karolina, Seeringer Angela, Kerl Kornelius, Buechner Jochen, Boos Joachim, Graf Norbert, Dürken Matthias, Gerss Joachim, Hasselblatt Martin, Kortmann Rolf-Dieter, Teichert von Luettichau Irene, Nagel Inga, Nygaard Randi, Oyen Florian, Quiroga Eduardo, Schlegel Paul-Gerhardt, Schmid Irene, Schneppenheim Reinhard, Siebert Reiner, Solano-Paez Palma, Timmermann Beate, Warmuth-Metz Monika, Frühwald Michael C..
Improved 6-year overall survival in AT/RT - results of the registry study rhabdoid 2007.
https://doi.org/10.1002/cam4.741
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Arnhold Viktor, Oyen Florian, Schneppenheim Reinhard, Haberl Hannes, Koch Arend, Frühwald Michael C., Hernáiz Driever Pablo.
Long-term survival of an infant with an atypical teratoid/rhabdoid tumor following subtotal resection and low-cumulative dose chemotherapy: a case report.
https://doi.org/10.1007/s00381-015-2999-5
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Sturm Dominik, Orr Brent A., Toprak Umut H., Hovestadt Volker, Jones David T.W., Capper David, Sill Martin, Buchhalter Ivo, Northcott Paul A., Leis Irina, Ryzhova Marina, Koelsche Christian, Pfaff Elke, Allen Sariah J., Balasubramanian Gnanaprakash, Worst Barbara C., Pajtler Kristian W., Brabetz Sebastian, Johann Pascal-David, Sahm Felix, Reimand Jüri, Mackay Alan, Carvalho Diana M., Remke Marc, Phillips Joanna J., Perry Arie, Cowdrey Cynthia, Drissi Rachid, Fouladi Maryam, Giangaspero Felice, Łastowska Maria, Grajkowska Wiesława, Scheurlen Wolfram, Pietsch Torsten, Hagel Christian, Gojo Johannes, Lötsch Daniela, Berger Walter, Slavc Irene, Haberler Christine, Jouvet Anne, Holm Stefan, Hofer Silvia, Prinz Marco, Keohane Catherine, Fried Iris, Mawrin Christian, Scheie David, Mobley Bret C., Schniederjan Matthew J., Santi Mariarita, Buccoliero Anna M., Dahiya Sonika, Kramm Christof M., von Bueren André O., von Hoff Katja, Rutkowski Stefan, Herold-Mende Christel, Frühwald Michael C., Milde Till, Hasselblatt Martin, Wesseling Pieter, Rößler Jochen, Schüller Ulrich, Ebinger Martin, Schittenhelm Jens, Frank Stephan, Grobholz Rainer, Vajtai Istvan, Hans Volkmar, Schneppenheim Reinhard, Zitterbart Karel, Collins V. Peter, Aronica Eleonora, Varlet Pascale, Puget Stephanie, Dufour Christelle, Grill Jacques, Figarella-Branger Dominique, Wolter Marietta, Schuhmann Martin U., Shalaby Tarek, Grotzer Michael, van Meter Timothy, Monoranu Camelia-Maria, Felsberg Jörg, Reifenberger Guido, Snuderl Matija, Forrester Lynn Ann, Koster Jan, Versteeg Rogier, Volckmann Richard, van Sluis Peter, Wolf Stephan, Mikkelsen Tom, Gajjar Amar, Aldape Kenneth, Moore Andrew S., Taylor Michael D., Jones Chris, Jabado Nada, Karajannis Matthias A., Eils Roland, Schlesner Matthias, Lichter Peter, Deimling Andreas von, Pfister Stefan M., Ellison David W., Korshunov Andrey, Kool Marcel.
New brain tumor entities emerge from molecular classification of CNS-PNETs.
https://doi.org/10.1016/j.cell.2016.01.015
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Worst Barbara C., van Tilburg Cornelis M., Balasubramanian Gnana Prakash, Fiesel Petra, Witt Ruth, Freitag Angelika, Boudalil Miream, Previti Christopher, Wolf Stephan, Schmidt Sabine, Chotewutmontri Sasithorn, Bewerunge-Hudler Melanie, Schick Matthias, Schlesner Matthias, Hutter Barbara, Taylor Lenka, Borst Tobias, Sutter Christian, Bartram Claus R., Milde Till, Pfaff Elke, Kulozik Andreas E., Stackelberg Arend von, Meisel Roland, Borkhardt Arndt, Reinhardt Dirk, Klusmann Jan-Henning, Fleischhack Gudrun, Tippelt Stephan, Dirksen Uta, Jürgens Heribert, Kramm Christof M., Bueren Andre O. von, Westermann Frank, Fischer Matthias, Burkhardt Birgit, Wößmann Wilhelm, Nathrath Michaela, Bielack Stefan S., Frühwald Michael C., Fulda Simone, Klingebiel Thomas, Koscielniak Ewa, Schwab Matthias, Tremmel Roman, Driever Pablo Hernáiz, Schulte Johannes H., Brors Benedikt, Deimling Andreas von, Lichter Peter, Eggert Angelika, Capper David, Pfister Stefan M., Jones David T. W., Witt Olaf.
Next-generation personalised medicine for high-risk paediatric cancer patients – the INFORM pilot study.
https://doi.org/10.1016/j.ejca.2016.06.009
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Hasselblatt Martin, Thomas Christian, Hovestadt Volker, Schrimpf Daniel, Johann Pascal-David, Bens Susanne, Oyen Florian, Peetz-Dienhart Susanne, Crede Yvonne, Wefers Annika, Vogel Hannes, Riemenschneider Markus J., Antonelli Manila, Giangaspero Felice, Bernardo Marie Christine, Giannini Caterina, Ud Din Nasir, Perry Arie, Keyvani Kathy, van Landeghem Frank, Sumerauer David, Hauser Peter, Capper David, Korshunov Andrey, Jones David T. W., Pfister Stefan M., Schneppenheim Reinhard, Siebert Reiner, Frühwald Michael C., Kool Marcel.
Poorly differentiated chordoma with SMARCB1/INI1 loss: a distinct molecular entity with dismal prognosis.
https://doi.org/10.1007/s00401-016-1574-9
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Kerl K., Oyen F., Giannikopoulou D., Rössig C., Rellensmann G., Sandkötter J., Brentrup A., Selzer G., Schneppenheim R., Frühwald Michael C..
Rapid diagnosis of an AT/RT by the detection of a heterozygous SMARCB1 germ line deletion in an infant.
https://doi.org/10.1002/pbc.25996
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Blümel Lena, Kerl Kornelius, Picard Daniel, Frühwald Michael C., Liebau Max C., Reifenberger Guido, Borkhardt Arndt, Hasselblatt Martin, Remke Marc.
Targeting primary ciliogenesis in atypical teratoid/rhabdoid tumors.
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Nemes Karolina, Frühwald Michael C., Hasselblatt Martin, Siebert Reiner, Kordes Uwe, Kool Marcel.
The integration of molecular and clinical data defines novel risk groups in atypical teratoid/rhabdoid tumors (AT/RT).
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Cseh Annamaria M., Niemeyer Charlotte M., Yoshimi Ayami, Catala Albert, Frühwald Michael C., Hasle Henrik, van den Heuvel-Eibrink Mary M., Lauten Melchior, De Moerloose Barbara, Smith Owen P., Bernig Toralf, Gruhn Bernd, Kulozik Andreas E., Metzler Markus, Olcay Lale, Suttorp Meinolf, Furlan Ingrid, Strahm Brigitte, Flotho Christian.
Therapy with low-dose azacitidine for MDS in children and young adults: a retrospective analysis of the EWOG-MDS study group.
https://doi.org/10.1111/bjh.13915
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2015 |
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Unland R., Matuszcak C., Clemens D., Kool M., Dirksen U., Frühwald Michael C..
Analysis of the antiproliferative effects of 3-deazaneoplanocin A in combination with standard anticancer agents in rhabdoid tumor cell lines.
https://doi.org/10.1097/CAD.0000000000000181
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Kerl K., Oyen F., Leuschner I., Schneppenheim R., Nagel I., Siebert R., Groll A. H., Hartmann W., Barth P. J., Bartelheim K., Seringer A., Wardelmann E., Frühwald Michael C..
Detection of SMARCB1 loss in ascites cells in the diagnosis of an abdominal rhabdoid tumor.
https://doi.org/10.1002/pbc.25412
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Mauz-Körholz C., Hasenclever D., Holzendorf V., Bernstädt M., Juergens H., Burdach S., Eggert A., Berthold F., Müller H. L., Frühwald Michael C., Klingebiel T. E., Metzler M., Körholz D..
Feasibility of VECOPA, a dose-intensive chemotherapy regimen for children and adolescents with intermediate and advanced stage Hodgkin lymphoma: results of the GPOH-HD-2002/VECOPA pilot trial.
https://doi.org/10.3109/10428194.2014.961011
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Zils Katja, Klingebiel Thomas, Behnisch Wolfgang, Mueller Hermann L., Schlegel Paul-Gerhardt, Frühwald Michael C., Suttorp Meinolf, Simon Thorsten, Werner Mathias, Bielack Stefan.
Osteosarcoma in patients with Rothmund–Thomson syndrome.
https://doi.org/10.3109/08880018.2014.987939
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Goedecke Simon, Mühlisch Jörg, Hempel Georg, Frühwald Michael C., Wünsch Bernhard.
Quantitative analysis of DNA methylation in the promoter region of the methylguanine-O6-DNA-methyltransferase gene by COBRA and subsequent native capillary gel electrophoresis.
https://doi.org/10.1002/elps.201500242
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Schaller Tina, Bode Markus, Berlis Ansgar, Frühwald Michael C., Lichtmannegger Ines, Endhardt Katharina, Märkl Bruno.
Specific immunohistochemical pattern of carbonic anhydrase IX is helpful for the diagnosis of CNS hemangioblastoma.
https://doi.org/10.1016/j.prp.2015.03.003
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Tallen Gesche, Resch Anika, Calaminus Gabriele, Wiener Andreas, Leiss Ulrike, Pletschko Thomas, Friedrich Carsten, Langer Thorsten, Grabow Desiree, Driever Pablo Hernáiz, Kortmann Rolf-Dieter, Timmermann Beate, Pietsch Torsten, Warmuth-Metz Monika, Bison Brigitte, Thomale Ulrich-Wilhelm, Krauss Jürgen, Mynarek Martin, Hoff Katja von, Ottensmeier Holger, Frühwald Michael C., Kramm Christof M., Temming Petra, Müller Hermann L., Witt Olaf, Kordes Uwe, Fleischhack Gudrun, Gnekow Astrid K., Rutkowski Stefan.
Strategies to improve the quality of survival for childhood brain tumour survivors.
https://doi.org/10.1016/j.ejpn.2015.07.011
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Unland R., Clemens D., Heinicke U., Potratz J. C., Hotfilder M., Fulda S., Wardelmann E., Frühwald Michael C., Dirksen U..
Suberoylanilide hydroxamic acid synergistically enhances the antitumor activity of etoposide in Ewing sarcoma cell lines.
https://doi.org/10.1097/CAD.0000000000000256
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Jeibmann A., Schulz J., Thiel K., Tegeder I., Johann Pascal-David, Kool M., Paulus W., Frühwald Michael C., Hasselblatt M..
TGF-BETA signaling is involved in the detrimental effects of smarcb1 deficiency in atypical teratoid/rhabdoid tumors.
https://doi.org/10.1002/pbc.25715
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2014 |
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Kerl Kornelius, Moreno Natalia, Holsten Till, Ahlfeld Julia, Mertins Julius, Hotfilder Marc, Kool Marcel, Bartelheim Kerstin, Schleicher Sabine, Handgretinger Rupert, Schüller Ulrich, Meisterernst Michael, Frühwald Michael C..
Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1.
https://doi.org/10.1002/ijc.28719
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Johann Pascal-David, Korshunov A., Ryzhova M., Kerl K., Milde T., Witt O., Jones D. T. W., Hovestadt V., Gajjar A., Hasselblatt M., Frühwald Michael C., Pfister S., Kool M..
Atypical teratoid/rhabdoid tumour is a heterogeneous entity that comprises subgroups with distinct molecular profiles.
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Johann Pascal-David, Korshunov Andrey, Kerl Kornelius, Huang Annie, Jabado Nada, Hasselblatt Martin, Frühwald Michael C., Pfister Stefan, Kool Marcel.
CNS AT/RTs are a heterogeneous entity that comprises subgroups with distinct molecular profiles.
https://doi.org/10.1016/j.cancergen.2014.09.011
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Benesch M., Warmuth-Metz M., von Bueren A. O., Hoffmann M., Pietsch T., Kortmann R.-D., Eyrich M., Graf N., Rutkowski S., Frühwald Michael C., Faber J., Kramm C..
Centrally reviewed gliomatosis cerebri in children and adolescents: a retrospecitve analysis from the HIT-HGG database.
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Bartelheim Kerstin, Sumerauer David, Behrends Uta, Kodetova Daniela, Kucera Filip, Leuschner Ivo, Neumayer Petra, Oyen Florian, Rübe Christian, Siebert Reiner, Schneppenheim Reinhard, Seeringer Angela, Vasovcak Peter, Frühwald Michael C..
Clinical and genetic features of rhabdoid tumors of the heart registered with the European Rhabdoid Registry (EU-RHAB).
https://doi.org/10.1016/j.cancergen.2014.04.005
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Bartelheim K., Seeringer A., Leuschner I., Schenk J. P., Timmermann B., Rübe C., Graf N., Koscielniak E., Schneppenheim R., Siebert R., Frühwald Michael C..
Clinical characteristics and outcome of children with extracranial, extrarenal rhabdoid tumors registered to the European Rhabdoid Registry 2007–2013.
https://doi.org/10.1016/j.cancergen.2014.09.031
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Seeringer Angela, Bartelheim Kerstin, Bourdeaut Franck, Graf Norbert, Frühwald Michael C..
Congenital rhabdoid tumors – feasibility of aggressive multimodal therapy in the youngest.
https://doi.org/10.1016/j.cancergen.2014.09.046
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Mertins J., Kornelius Kornelius, Moreno N., Holsten T., Frühwald Michael C., Kool M., Meisterernst M..
EZH2 regulates the expression of DNMTs in malignant rhabdoid tumors.
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Unland Rebekka, Kerl Kornelius, Schlosser Sabrina, Farwick Nicole, Plagemann Tanja, Lechtape Birigit, Clifford Steven C., Kreth Jonas H., Gerss Joachim, Mühlisch Jörg, Richter Günther H. S., Hasselblatt Martin, Frühwald Michael C..
Epigenetic repression of the dopamine receptor D4 in pediatric tumors of the central nervous system.
https://doi.org/10.1007/s11060-013-1313-1
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Kordes U., Bartelheim K., Massimino M., Biassoni V., Reinhard H., Hasselblatt M., Schneppenheim R., Frühwald Michael C..
Favorable outcome of patients affected by rhabdoid tumors due to rhabdoid tumor predisposition syndrome (RTPS).
https://doi.org/10.1002/pbc.24793
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Mauz-Körholz C., Hasenclever D., Holzendorf V., Jürgens H., Burdach S., Eggert A., Berthold F., Müller H., Frühwald Michael C., Klingebiel T., Metzler M., Körholz D..
Feasibility of VECOPA a dose-intensive regimen for pediatric intermediate and advanced stage Hodgkin's lymphoma: results of the GPOH-HD-2002/VECOPA-pilot study.
https://doi.org/10.1055/s-0034-1371126
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Seeringer A., Bartelheim K., Kerl K., Hasselblatt M., Leuschner I., Rutkowski S., Timmermann B., Kortmann R.-D., Koscielniak E., Schneppenheim R., Warmuth-Metz M., Gerß J., Siebert R., Graf N., Boos J., Frühwald Michael C..
Feasibility of intensive multimodal therapy in infants affected by Rhabdoid tumors – experience of the EU-RHAB registry.
https://doi.org/10.1055/s-0034-1368719
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Hasselblatt M., Schüller U., Junckerstorff R., Rosenblum M. K., Alassiri A., Rossi S., Bartelheim K., Schmid I., Gottardo N., Toledano H., Viscardi E., Witkowski L., Nagel I., Oyen F., Foulkes W. D., Paulus W., Siebert R., Schneppenheim R., Frühwald Michael C..
Genetic alterations of SMARCA4 in atypical teratoid/rhabdoid tumours (AT/RT) are associated with higher frequency of germ line alterations and shorter survival as compared to SMARCB1 deficient AT/RT.
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Benesch M., Bartelheim K., Fleischhack G., Gruhn B., Schlegel P. G., Witt O., Stachel K. D., Hauch H., Urban C., Quehenberger F., Massimino M., Pietsch T., Hasselblatt M., Giangaspero F., Kordes U., Schneppenheim R., Hauser P., Klingebiel T., Frühwald Michael C..
High-dose chemotherapy (HDCT) with auto-SCT in children with atypical teratoid/rhabdoid tumors (AT/RT): a report from the European Rhabdoid Registry (EU-RHAB).
https://doi.org/10.1038/bmt.2013.208
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Hasselblatt M., Jeibmann A., Eikmeier K., Linge A., Johann Pascal-David, Koos B., Bartelheim K., Kool M., Pfister S. M., Frühwald Michael C., Paulus W..
Hippo signaling is essential for the phenotype associated with SNR1 loss in drosophila melanogaster and involved in the biology of SMARCB1-deficient atypical teratoid/rhabdoid tumors.
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Jeibmann Astrid, Eikmeier Kristin, Linge Anna, Kool Marcel, Koos Björn, Schulz Jacqueline, Albrecht Stefanie, Bartelheim Kerstin, Frühwald Michael C., Pfister Stefan M., Paulus Werner, Hasselblatt Martin.
Identification of genes involved in the biology of atypical teratoid/rhabdoid tumours using Drosophila melanogaster.
https://doi.org/10.1038/ncomms5005
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Vu-Han T., Frühwald Michael C., Hasselblatt M., Oyen F., Obser T., Siebert R., Schneppenheim R..
Identifying molecular markers for the sensitive detection of residual AT/RT cells.
https://doi.org/10.1055/s-0034-1374844
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Vu-Han Tu-Lan, Frühwald Michael C., Hasselblatt Martin, Kerl Kornelius, Nagel Inga, Obser Tobias, Oyen Florian, Siebert Reiner, Schneppenheim Reinhard.
Identifying molecular markers for the sensitive detection of residual atypical teratoid rhabdoid tumor cells.
https://doi.org/10.1016/j.cancergen.2014.05.008
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Bartelheim K., Benesch M., Buchner J., Gress J., Hasselblatt M., Kortmann R.-D., Fleischhack G., Quiroga E., Reinhard H., Schneppenheim R., Seeringer A., Siebert R., Timmermann B., Warmuth-Metz M., Schmid I., Frühwald Michael C..
Improved 5-year overall survival in 23 patients with AT/RT treated according to the rhabdoid 2007 regimen of the EU-RHAB registry.
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Schwake Michael, Günes Dennis, Köchling Michaela, Brentrup Angela, Schroeteler Juliane, Hotfilder Marc, Frühwald Michael C., Stummer Walter, Ewelt Christian.
Kinetics of porphyrin fluorescence accumulation in pediatric brain tumor cells incubated in 5-aminolevulinic acid.
https://doi.org/10.1007/s00701-014-2096-7
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Frühwald Michael C., Bartelheim K., Seeringer A., Kerl K., Kortmann R.-D., Warmuth-Metz M., Hasselblatt M., Schneppenheim R., Siebert R., Klingebiel T. E..
Longterm remission of high risk AT/RT despite inoperability and widespread metastasis - the EU-RHAB strategy.
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Furtwängler R., Nourkamie-Tutdibi N., Leuschner I., Vokuhl C., Niggli F. K., Kager L., Frühwald Michael C., Graf N..
Malignant rhabdoid tumor of the kidney (MRTK) - data of 52 patients treated according to protocols of the GPOH (German Society of Paediatric Oncology and Hematology).
https://doi.org/10.1002/pbc.25314
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Furtwängler R., Nourkami-Tutibi N., Leuschner I., Niggli F., Kager L., Frühwald Michael C., Graf N..
Malignant rhabdoid tumor of the kidney (MRTK) – data of 52 patients treated according to protocols of the GPOH (German Society of Paediatric Oncology and Haematology).
https://doi.org/10.1016/j.cancergen.2014.09.032
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Furtwängler Rhoikos, Nourkami-Tutdibi Nasinien, Leuschner Ivo, Vokuhl Christian, Niggli Felix, Kager Leo, Ebinger Martin, Frühwald Michael C., Graf Norbert.
Malignant rhabdoid tumor of the kidney: significantly improved response to pre-operative treatment intensified with doxorubicin.
https://doi.org/10.1016/j.cancergen.2014.07.001
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Hasselblatt Martin, Brokinkel Benjamin, Bartelheim Kerstin, Schneppenheim Reinhard, Siebert Reiner, Frühwald Michael C..
Prognostic value of clinical, histopathological and molecular features in AT/RT.
https://doi.org/10.1016/j.cancergen.2014.09.018
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Brecht I. B., Bremensdorfer C., Schneider D. T., Frühwald Michael C., Offenmüller S., Mertens R., Vorwerk P., Bielack S. S., Benesch M., Hero B., Graf N., Schweinitz D. von, Kaatsch P..
Rare malignant pediatric tumors registered in the German Childhood Cancer Registry 2001-2010.
https://doi.org/10.1002/pbc.24997
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Bourdeaut Franck, Chi Susan N., Frühwald Michael C..
Rhabdoid tumors: integrating biological insights with clinical success.
https://doi.org/10.1016/j.cancergen.2014.10.004
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Hasselblatt Martin, Nagel Inga, Oyen Florian, Bartelheim Kerstin, Russell Robert B., Schüller Ulrich, Junckerstorff Reimar, Rosenblum Marc, Alassiri Ali H., Rossi Sabrina, Schmid Irene, Gottardo Nicholas G., Toledano Helen, Viscardi Elisabetta, Balbin Milagros, Witkowski Leora, Lu Qianhao, Betts Matthew J., Foulkes William D., Siebert Reiner, Frühwald Michael C., Schneppenheim Reinhard.
SMARCA4-mutated atypical teratoid/rhabdoid tumors are associated with inherited germline alterations and poor prognosis.
https://doi.org/10.1007/s00401-014-1323-x
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Seeringer Angela, Reinhard Harald, Hasselblatt Martin, Schneppenheim Reinhard, Siebert Reiner, Bartelheim Kerstin, Leuschner Ivo, Frühwald Michael C..
Synchronous congenital malignant rhabdoid tumor of the orbit and atypical teratoid/rhabdoid tumor - feasibility and efficacy of multimodal therapy in a long-term survivor.
https://doi.org/10.1016/j.cancergen.2014.06.028
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Seeringer A., Bartelheim K., Kerl K., Timmermann B., Kortmann R. D., Schneppenheim R., Warmuth-Metz M., Gerss J., Siebert R., Graf N., Boos J., Nysom K., Frühwald Michael C..
Treatment options and clinical outcome in infants with AT/RT.
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2013 |
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Warmuth-Metz M., Bison Brigitte, Gerber N. U., Pietsch T., Hasselblatt M., Frühwald Michael C..
Bone involvement in atypical teratoid/rhabdoid tumors of the CNS.
https://doi.org/10.3174/ajnr.a3554
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Hasselblatt Martin, Isken Sarah, Linge Anna, Eikmeier Kristin, Jeibmann Astrid, Oyen Florian, Nagel Inga, Richter Julia, Bartelheim Kerstin, Kordes Uwe, Schneppenheim Reinhard, Frühwald Michael C., Siebert Reiner, Paulus Werner.
High-resolution genomic analysis suggests the absence of recurrent genomic alterations other than SMARCB1 aberrations in atypical teratoid/rhabdoid tumors.
https://doi.org/10.1002/gcc.22018
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Kerl Kornelius, Holsten Till, Frühwald Michael C..
Rhabdoid tumors: clinical approaches and molecular targets for innovative therapy.
https://doi.org/10.3109/08880018.2013.791737
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Remke Marc, Hering Esther, Gerber Nicolas U., Kool Marcel, Sturm Dominik, Rickert Christian H., Gerß Joachim, Schulz Stefan, Hielscher Thomas, Hasselblatt Martin, Jeibmann Astrid, Hans Volkmar, Ramaswamy Vijay, Taylor Michael D., Pietsch Torsten, Rutkowski Stefan, Korshunov Andrey, Monoranu Carmelia-Maria, Frühwald Michael C..
Somatostatin receptor subtype 2 (sst2) is a potential prognostic marker and a therapeutic target in medulloblastoma.
https://doi.org/10.1007/s00381-013-2142-4
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Corbacioglu Selim, Steinbach Daniel, Lode Holger N., Gruhn Bernd, Frühwald Michael C., Broeckelmann Mechthild, Suttorp Meinolf, Escherich Gabriele, Cario Gunnar, Ehlert Karoline, Meister Bernhard, Simon Thorsten, Debatin Klaus-Michael, Kuhlen Michaela, Feddersen Isa.
The RIST design: a molecularly targeted multimodal approach for the treatment of patients with relapsed and refractory neuroblastoma.
https://doi.org/10.1200/jco.2013.31.15_suppl.10017
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Kerl Kornelius, Ries David, Unland Rebecca, Borchert Christiane, Moreno Natalia, Hasselblatt Martin, Jürgens Heribert, Kool Marcel, Görlich Dennis, Eveslage Maria, Jung Manfred, Meisterernst Michael, Frühwald Michael C..
The histone deacetylase inhibitor SAHA acts in synergism with fenretinide and doxorubicin to control growth of rhabdoid tumor cells.
https://doi.org/10.1186/1471-2407-13-286
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2012 |
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Walden Ulrike, Frühwald Michael C..
Altbekanntes, neue Leitlinien und zukünftige Herausforderungen: Harnwegsinfekte im Kindes- und Jugendalter.
https://doi.org/10.1007/s00092-012-0297-z
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Doege Corinna, Pritsch Maria, Frühwald Michael C., Bauer Jacqueline.
An association between infantile haemangiomas and erythropoietin treatment in preterm infants.
https://doi.org/10.1136/adc.2010.187344
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Ko Kinarm, Wu Guangming, Araúzo-Bravo Marcos J., Kim Julee, Francine Jury, Greber Boris, Mühlisch Jörg, Joo Jin Young, Sabour Davood, Frühwald Michael C., Tapia Natalia, Schöler Hans R..
Autologous pluripotent stem cells generated from adult mouse testicular biopsy.
https://doi.org/10.1007/s12015-011-9307-x
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Boxberger N., Redlich A., Frühwald Michael C., Schweinitz D. von, Bucsky P. P., Vorwerk P..
Children and adolescents with adrenocortical carcinomas in Germany - results of the GPOH-MET 97 trial.
https://doi.org/10.1002/pbc.24295
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Jones David T. W., Jäger Natalie, Kool Marcel, Zichner Thomas, Hutter Barbara, Sultan Marc, Cho Yoon-Jae, Pugh Trevor J., Hovestadt Volker, Stütz Adrian M., Rausch Tobias, Warnatz Hans-Jörg, Ryzhova Marina, Bender Sebastian, Sturm Dominik, Pleier Sabrina, Cin Huriye, Pfaff Elke, Sieber Laura, Wittmann Andrea, Remke Marc, Witt Hendrik, Hutter Sonja, Tzaridis Theophilos, Weischenfeldt Joachim, Raeder Benjamin, Avci Meryem, Amstislavskiy Vyacheslav, Zapatka Marc, Weber Ursula D., Wang Qi, Lasitschka Bärbel, Bartholomae Cynthia C., Schmidt Manfred, Kalle Christof von, Ast Volker, Lawerenz Chris, Eils Jürgen, Kabbe Rolf, Benes Vladimir, van Sluis Peter, Koster Jan, Volckmann Richard, Shih David, Betts Matthew J., Russell Robert B., Coco Simona, Paolo Tonini Gian, Schüller Ulrich, Hans Volkmar, Graf Norbert, Kim Yoo-Jin, Monoranu Camelia, Roggendorf Wolfgang, Unterberg Andreas, Herold-Mende Christel, Milde Till, Kulozik Andreas E., Deimling Andreas von, Witt Olaf, Maass Eberhard, Rössler Jochen, Ebinger Martin, Schuhmann Martin U., Frühwald Michael C., Hasselblatt Martin, Jabado Nada, Rutkowski Stefan, von Bueren André O., Williamson Dan, Clifford Steven C., McCabe Martin G., Peter Collins V., Wolf Stephan, Wiemann Stefan, Lehrach Hans, Brors Benedikt, Scheurlen Wolfram, Felsberg Jörg, Reifenberger Guido, Northcott Paul A., Taylor Michael D., Meyerson Matthew, Pomeroy Scott L., Yaspo Marie-Laure, Korbel Jan O., Korshunov Andrey, Eils Roland, Pfister Stefan M., Lichter Peter.
Dissecting the genomic complexity underlying medulloblastoma.
https://doi.org/10.1038/nature11284
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Schwartzentruber Jeremy, Korshunov Andrey, Liu Xiao-Yang, Jones David T. W., Pfaff Elke, Jacob Karine, Sturm Dominik, Fontebasso Adam M., Quang Dong-Anh Khuong, Tönjes Martje, Hovestadt Volker, Albrecht Steffen, Kool Marcel, Nantel Andre, Konermann Carolin, Lindroth Anders, Jäger Natalie, Rausch Tobias, Ryzhova Marina, Korbel Jan O., Hielscher Thomas, Hauser Peter, Garami Miklos, Klekner Almos, Bognar Laszlo, Ebinger Martin, Schuhmann Martin U., Scheurlen Wolfram, Pekrun Arnulf, Frühwald Michael C., Roggendorf Wolfgang, Kramm Christoph, Dürken Matthias, Atkinson Jeffrey, Lepage Pierre, Montpetit Alexandre, Zakrzewska Magdalena, Zakrzewski Krzystof, Liberski Pawel P., Dong Zhifeng, Siegel Peter, Kulozik Andreas E., Zapatka Marc, Guha Abhijit, Malkin David, Felsberg Jörg, Reifenberger Guido, Deimling Andreas von, Ichimura Koichi, Collins V. Peter, Witt Hendrik, Milde Till, Witt Olaf, Zhang Cindy, Castelo-Branco Pedro, Lichter Peter, Faury Damien, Tabori Uri, Plass Christoph, Majewski Jacek, Pfister Stefan M., Jabado Nada.
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma.
https://doi.org/10.1038/nature10833
BibTeX | RIS | DOI Corrigendum published at: https://doi.org/10.1038/nature11026 |
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Borchardt C., Unland R., Clemens D., Kerl K., Hempel G., Frühwald Michael C..
Effects of histone methyltransferase inhibitor 3-Deazaneoplanocin (DZNep) on rhabdoid tumor cell lines.
https://doi.org/10.1055/s-0032-1320170
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Unland R., Schlosser S., Farwick N., Plagemann T., Richter G., Jürgens H., Frühwald Michael C..
Epigenetic deregulation of the dopamine receptor D4 in pediatric brain tumors.
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Unland R., Schlosser S., Farwick N., Plagemann T., Richter G., Jürgens H., Frühwald Michael C..
Epigenetic silencing of the dopamine receptor D4 in medulloblastoma.
https://doi.org/10.1055/s-0032-1320172
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Hasselblatt M., Isken S., Kordes U., Siebert R., Schneppenheim R., Frühwald Michael C., Paulus W..
Genome wide copy number analysis of atypical Teratoid/Rhabdoid tumors using Formalin-fixed tissues.
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Benesch M., Fleischhack G., Gruhn B., Schlegel P.-G., Witt G., Holter W., Reiter A., Urban C., Frühwald Michael C..
High-Dose chemotherapy (HDCT) with autologous peripheral blood stem cell transplantation (APBSCT) in children with atypical teratoid/rhabdoid tumors (AT/RT): a report from The European Rhabdoid Registry (EU-RHAB).
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Sturm Dominik, Witt Hendrik, Hovestadt Volker, Khuong-Quang Dong-Anh, Jones David T.W., Konermann Carolin, Pfaff Elke, Tönjes Martje, Sill Martin, Bender Sebastian, Kool Marcel, Zapatka Marc, Becker Natalia, Zucknick Manuela, Hielscher Thomas, Liu Xiao-Yang, Fontebasso Adam M., Ryzhova Marina, Albrecht Steffen, Jacob Karine, Wolter Marietta, Ebinger Martin, Schuhmann Martin U., van Meter Timothy, Frühwald Michael C., Hauch Holger, Pekrun Arnulf, Radlwimmer Bernhard, Niehues Tim, von Komorowski Gregor, Dürken Matthias, Kulozik Andreas E., Madden Jenny, Donson Andrew, Foreman Nicholas K., Drissi Rachid, Fouladi Maryam, Scheurlen Wolfram, Deimling Andreas von, Monoranu Camelia, Roggendorf Wolfgang, Herold-Mende Christel, Unterberg Andreas, Kramm Christof M., Felsberg Jörg, Hartmann Christian, Wiestler Benedikt, Wick Wolfgang, Milde Till, Witt Olaf, Lindroth Anders M., Schwartzentruber Jeremy, Faury Damien, Fleming Adam, Zakrzewska Magdalena, Liberski Pawel P., Zakrzewski Krzysztof, Hauser Peter, Garami Miklos, Klekner Almos, Bognar Laszlo, Morrissy Sorana, Cavalli Florence, Taylor Michael D., van Sluis Peter, Koster Jan, Versteeg Rogier, Volckmann Richard, Mikkelsen Tom, Aldape Kenneth, Reifenberger Guido, Collins V. Peter, Majewski Jacek, Korshunov Andrey, Lichter Peter, Plass Christoph, Jabado Nada, Pfister Stefan M..
Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of Glioblastoma.
https://doi.org/10.1016/j.ccr.2012.08.024
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Zoghbi A., Meisterernst M., Frühwald Michael C., Kerl K..
Impact of BRD4 inhibition on multiple pediatric cancers focusing on embryonic tumors.
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Kerl Kornelius, Nowacki Meike, Leuschner Ivo, Masjosthusmann Katja, Frühwald Michael C..
Infantile fibrosarcoma - an important differential diagnosis of congenital vascular tumors.
https://doi.org/10.3109/08880018.2012.705231
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Ehlert Karoline, Groll Andreas H., Rossig Claudia, Frühwald Michael C., Juergens Heribert.
Late graft failure in FA - case report and review of the literature.
https://doi.org/10.1111/j.1399-3046.2012.01719.x
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Krzyzankova Miroslava, Mertsch Sonja, Koos Björn, Jeibmann Astrid, Kruse Anne, Kordes Uwe, Frühwald Michael C., Wolff Johannes E., Paulus Werner, Hasselblatt Martin.
Loss of TP53 expression in immortalized choroid plexus epithelial cells results in increased resistance to anticancer agents.
https://doi.org/10.1007/s11060-012-0915-3
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Tenardi R. D., Frühwald Michael C., Jürgens H., Hertroijs D., Bauer J..
Nutritional status of children and young adults with Ewing sarcoma or osteosarcoma at diagnosis and during multimodality therapy.
https://doi.org/10.1002/pbc.24001
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Warmuth-Metz Monika, Frühwald Michael C..
Pediatric atypical teratoid/rhabdoid tumors: imaging with CT and MRI.
https://doi.org/10.1007/978-94-007-2957-5_4
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Hasselblatt M., Kordes U., Wolff J., Jeibmann A., Frühwald Michael C., Paulus W..
Pitfalls in the diagnosis of atypical teratoid/rhabdoid tumors (AT/RT): experiences from The European Rhabdoid Tumor Registry (EURHAB) and The International Choroid Plexus Tumor Registry CPT-SIOP.
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Bartelheim K., Benesch M., Buechner J., Devenney I., Gerss J., Gil-Da-Costa M. J., Graf N., Hasselblatt M., Hauser P., Kortmann P.-D., Koscielniak E., Leuschner I., Massimino M., Nysom K., Perek-Polnik M., Quiroga E., Schneppenheim R., Schroeder H., Siebert R., Sumerauer D., Timmermann B., van de Wetering M. D., Warmuth-Metz M., Frühwald Michael C..
Rhabdoid 2007 and EU-RHAB - results of two European registries with consensus treatment recommendations for 139 children with rhabdoid tumors.
https://doi.org/10.1002/pbc.24295
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Bartelheim K., Hasselblatt M., Warmuth-Metz M., Kortmann R.-D., Gerss J., Schneppenheim R., Siebert R., Frühwald Michael C..
Rhabdoid 2007: 5 year follow-up of a consensus treatment regimen in 29 german children with AT/RT.
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Redlich A., Boxberger N., Werner S. K., Frühwald Michael C., Rohrer T., Vorwerk P..
Sensitivity of fine-needle biopsy in detecting pediatric differentiated thyroid carcinoma.
https://doi.org/10.1002/pbc.24051
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Kerl K., Unland R., Jürgens H., Frühwald Michael C..
Synergistic effects of a combination of HDAC inhibitors with EZH2 or cyclind inhibitors on rhabdoid tumor cell growth.
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Redlich A., Boxberger N., Strugala D., Frühwald Michael C., Leuschner I., Kropf S., Bucsky P., Vorwerk P..
Systemic treatment of adrenocortical carcinoma in children: data from the German GPOH-MET 97 trial.
https://doi.org/10.1055/s-0032-1327579
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Grunewald T. G., Greulich N., Kontny U., Frühwald Michael C., Rutkowski S., Kordes U., Scheurlen W., Schmidt W., Stachel D., Metzler M., Mittler U., Graf N., Benesch M., Burdach S..
Targeted therapeutics in treatment of children and young adults with solid tumors: an expert survey and review of the literature.
https://doi.org/10.1055/s-0032-1301930
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Friedrich C., Gnekow Astrid K., Fleischhack G., Kramm C. M., Frühwald Michael C., Mueller H. L., Calaminus G., Kordes U., Faldum A., Pietsch T., Warmuth-Metz M., Kortmann R. D., Jung I., Kaatsch P., Rutkowski S..
What is the real incidence of pediatric brain tumors? 10 year experience of The German National Pediatric Brain Tumor Network Hit.
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2011 |
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Stelljes M., Corbacioglu A., Schlenk R. F., Döhner K., Frühwald Michael C., Rossig C., Ehlert K., Silling G., Müller-Tidow C., Juergens H., Döhner H., Berdel W. E., Kienast J., Koschmieder S..
Allogeneic stem cell transplant to eliminate germline mutations in the gene for CCAAT-enhancer-binding protein α from hematopoietic cells in a family with AML.
https://doi.org/10.1038/leu.2011.64
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Antonelli Manila, Hasselblatt Martin, Haberler Christine, Di Giannatale Angela, Garrè Maria L., Donofrio Vittoria, Lauriola Libero, Ridola Vita, Arcella Antonella, Frühwald Michael C., Giangaspero Felice.
Claudin-6 is of limited sensitivity and specificity for the diagnosis of atypical teratoid/rhabdoid tumors.
https://doi.org/10.1111/j.1750-3639.2011.00478.x
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Unland R., Schlosser S., Mühlisch J., Frühwald Michael C..
Epigenetic deregulation of the dopamine receptor D4 in pediatric brain tumors.
https://doi.org/10.1055/s-0031-1292595
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Hoff K. von, Hinkes B., Dannenmann-Stern E., Bueren A. O. von, Warmuth-Metz M., Soerensen N., Emser A., Zwiener I., Schlegel P. G., Kuehl J., Frühwald Michael C., Kortmann R. D., Pietsch T., Rutkowski S..
Frequency, risk-factors and survival of children with atypical teratoid rhabdoid tumors (AT/RT) of the CNS diagnosed between 1988 and 2004, and registered to the German HIT database.
https://doi.org/10.1002/pbc.23236
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Neuner Bruno, Mackensen Sylvia von, Krümpel Anne, Manner Daniela, Friefeld Sharon, Nixdorf Sarah, Frühwald Michael C., deVeber Gabrielle, Nowak-Göttl Ulrike.
Health-related quality of life in children and adolescents with stroke, self-reports, and parent/proxies reports: cross-sectional investigation.
https://doi.org/10.1002/ana.22381
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Bauer Jacqueline, Jürgens Heribert, Frühwald Michael C..
Important aspects of nutrition in children with cancer.
https://doi.org/10.3945/an.110.000141
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Sturm D., Remke M., Rizhova M., Witt H., Jacob K., Milde T., Witt O., Frühwald Michael C., Van Meter T. E., Kramm C., Reifenberger G., Felsberg J., Deimling Andreas von, Hartmann C., Kulozik A., Korshunov A., Jabado N., Lichter P., Pfister S. M., Lichter P..
Integrative genomics approach provides insight into molecular characteristics of pediatric glioblastoma.
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Pollard J. W., Danilkovitch-Miagkova A., Minaguchi T., Waite K. A., Buys T. P. H., Lam W. L., Müller-Hermelink H. K., Ott G., Robb V. A., Henske E. P., Lynge E., Boyd N., Geisler C., Seger R., De Wolf-Peeters C., Sagaert X., Sheng S., Ribatti D., Verstovsek S., Akin C., Stack M. S., Kitada S., Gartenhaus R., Moretti F., Frühwald Michael C., Mooi W. J., Krausz T., Kefford R., Peikert T., Specks U., Tueting T., Pföhler C., Blask D. E., Stevens R. G., Nies A. T., Gotoh N., Tsuchida N., Escriba P., Singh V., Hickey M., Saunders C., Xiao G.-H., Testa J. R., Furtwängler R., Scholler N., Carbone M., Furge K., Woude G. F. V., Roland W. C., Muschel R., Hunter K., Welch D. R., Vaidya K. S., Hurst D. R., Silveira A. C., Zang X. A., Bari R., Silveira A., Szmulewitz R., Taylor J., Rinker-Schaffer C., Shim H., Plass C., Lindsey J. C., Clifford S. C., Holdenrieder S., Steinle A., Salih H., Brown D. A., Breit S. N., Bauskin A. R., Mousses S., Lung M. L., Alix-Panabieres C., Pantel K., Djuzenova C. S., Dalmay T., Ahlquist T., Lothe R. A., Bhat K., Setaluri V., Rutka J. T., Salhia B., Cockell K. A., Radich J. P., Yamagishi S.-I., Bignami M., Verma M., Kumar D., Brenner C., Zhang Y.-W., Jamieson D., Chi Y.-H., Jeang K.-T., Roninson I., Dragani T., Sobolev A. S., Powers M. V., Workmann P., Evans M. F., Cooper K., Kausch I., Doehn C., Janz S., Huang C.-L., Toland A. E., Osinaga E., Kaye F., Lemos M. C., Thakker R. V., Teh B. T., Ponder B. A. J., Mulligan L. M., Gullo C., Klein G., Wu X., Araten D. J., Loeb L. A., Cheadle J. P., Lipsick J., Albihn A., Henriksson M., Kremens B., Germing U., Zangemeister-Wittke U., Simon H.-U., Yu Y. P., Luo J., Aman P..
Metalloenzymes.
https://doi.org/10.1007/978-3-642-16483-5_3663
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Pollard J. W., Danilkovitch-Miagkova A., Minaguchi T., Waite K. A., Buys T. P. H., Lam W. L., Müller-Hermelink H. K., Ott G., Robb V. A., Henske E. P., Lynge E., Boyd N., Geisler C., Seger R., De Wolf-Peeters C., Sagaert X., Sheng S., Ribatti D., Verstovsek S., Akin C., Stack M. S., Kitada S., Gartenhaus R., Moretti F., Frühwald Michael C., Mooi W. J., Krausz T., Kefford R., Peikert T., Specks U., Tueting T., Pföhler C., Blask D. E., Stevens R. G., Nies A. T., Gotoh N., Tsuchida N., Escriba P., Singh V., Hickey M., Saunders C., Xiao G.-H., Testa J. R., Furtwängler R., Scholler N., Carbone M., Furge K., Woude G. F. V., Roland W. C., Muschel R., Hunter K., Welch D. R., Vaidya K. S., Hurst D. R., Silveira A. C., Zang X. A., Bari R., Silveira A., Szmulewitz R., Taylor J., Rinker-Schaffer C., Shim H., Plass C., Lindsey J. C., Clifford S. C., Holdenrieder S., Steinle A., Salih H., Brown D. A., Breit S. N., Bauskin A. R., Mousses S., Lung M. L., Alix-Panabieres C., Pantel K., Djuzenova C. S., Dalmay T., Ahlquist T., Lothe R. A., Bhat K., Setaluri V., Rutka J. T., Salhia B., Cockell K. A., Radich J. P., Yamagishi S.-I., Bignami M., Verma M., Kumar D., Brenner C., Zhang Y.-W., Jamieson D., Chi Y.-H., Jeang K.-T., Roninson I., Dragani T., Sobolev A. S., Powers M. V., Workmann P., Evans M. F., Cooper K., Kausch I., Doehn C., Janz S., Huang C.-L., Toland A. E., Osinaga E., Kaye F., Lemos M. C., Thakker R. V., Teh B. T., Ponder B. A. J., Mulligan L. M., Gullo C., Klein G., Wu X., Araten D. J., Loeb L. A., Cheadle J. P., Lipsick J., Albihn A., Henriksson M., Kremens B., Germing U., Zangemeister-Wittke U., Simon H.-U., Yu Y. P., Luo J., Aman P..
Metallothionein enzymes.
https://doi.org/10.1007/978-3-642-16483-5_3667
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Sturm D., Remke M., Rhyzova M., Witt H., Jacob K., Milde T., Witt O., Frühwald Michael C., Van Meter T. E., Kramm C., Reifenberger G., Felsberg J., Deimling A., Hartmann C., Kulozik A., Korshunov A., Jabado N., Lichter P., Pfister S. M..
Molecular characterization of pediatric glioblastoma using an integrative genomics approach.
https://doi.org/10.1093/neuonc/nor018
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Hasselblatt M., Gesk S., Oyen F., Rossi S., Viscardi E., Giangaspero F., Giannini C., Judkins A. R., Frühwald Michael C., Obser T., Schneppenheim R., Siebert R., Paulus W..
Nonsense mutation and inactivation of SMARCA4 (BRG1) in an atypical teratoid/rhabdoid tumor showing retained SMARCB1 (INI1) expression.
https://doi.org/10.1097/PAS.0b013e3182196a39
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Kerl K., Sträter R., Hasselblatt M., Brentrup A., Frühwald Michael C..
Role of neoadjuvant chemotherapy in congenital intracranial haemangiopericytoma.
https://doi.org/10.1002/pbc.22726
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Militsakh O., Day T., Hornig J., Lentsch E., Skoner J., Gillespie M., Sharma A., Neville B., Rumboldt Z., James R., Goddard J., Shikata K., Doi Y., Rosen E. M., Goldberg I. D., Fan S., Kong L., Lu J. J., Chlenski A., Cohn S. L., Hlubek F., Qian C.-N., Teh B. T., Batistatou A., Charalbopoulos K., Christensen C., Reddel R., Ploeg I. M. C., Kroon B. B. R., Nieweg O. E., Rijk M. C., Winqvist O., Thorn M., Zwick C., Pfreundschuh M., Knudsen B. S., Lucas J., Nelson P., Kashikar N., Datta P. K., Hottinger A. F., Hormigo A., Knobler E., Knobler R., McCarty J. H., Bardia A., Loprinzi C., Buettner R., Jove R., Garcia R., Frank D. A., Nakatsura T., Witt O., Yoshida K., Chou P.-L., Tsay G. J., Takeuchi T., Furihata M., Robertson F. M., Werbowetski-Ogilvie T. E., Maestro R. F., Sadr M. S., Dennler S., Dijke P., Gadgeel S., Tierauch K.-H., Yip K. W., Liu F.-F., Cano A., Neto M. A., Rünger T. M., Frühwald Michael C., Trakhtenbrot L., Mi J., Larner J. M., Hamlin J. L., Radin N. S., Lo T. L., Guy G. R., Yeudall W. A., Parsons S. J., Fan F., Platanias L. C., Mcgahren-Murray M., Keyomarsi K., Kos J., Seigel G. M., Alison M. R., Hiyama E., Renehan A. G., Potten C. S., Tang D. G., Foster P., Lin K., Bergelt C., Ronai Z., Cukierman E., Aumercier M., Hodson M., Lolis E., Mehta A., Chung F.-L., Glatt H., Oberthür A., Warnat P., Aranda S., Culig Z., Chung B. H., Shin Y.-B., Kim M., Grevenstein W. M. U., van Eijck C. H. J., Baker S. G., Kramer B. S., Mahotka C., Carbone M., Yang H., Mueller S. C., Coopman P. J., Brujin D., Kessel A. D., George J. M..
Severe combined immunodeficiency disease.
https://doi.org/10.1007/978-3-642-16483-5_5270
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Yeudall W. A., Militsakh O., Day T., Hornig J., Lentsch E., Skoner J., Gillespie M., Sharma A., Neville B., Rumboldt Z., James R., Goddard J., Shikata K., Doi Y., Rosen E. M., Goldberg I. D., Fan S., Kong L., Lu J. J., Chlenski A., Cohn S. L., Hlubek F., Qian C.-N., T. B. T., Batistatou A., Charalbopoulos K., Christensen C., Reddel R., Ploeg I. M. C., Kroon B. B. R., Nieweg O. E., Rijk M. C., Winqvist O., Thorn M., Zwick C., Pfreundschuh M., Knudsen B. S., Lucas J., Nelson P., Kashikar N., Datta P. K., Hottinger A. F., Hormigo A., Knobler E., Knobler R., McCarty J. H., Bardia A., Loprinzi C., Buettner R., Jove R., Garcia R., Frank D. A., Nakatsura T., Witt O., Yoshida K., Chou P.-L., Tsay G. J., Takeuchi T., Furihata M., Robertson F. M., Werbowetski-Ogilvie T. E., Maestro R. F., Sadr M. S., Dennler S., Dijke P., Gadgeel S., Tierauch K.-H., Yip K. W., Liu F.-F., Cano A., Neto M. A., Rünger T. M., Frühwald Michael C., Trakhtenbrot L., Mi J., Larner J. M., Hamlin J. L., Radin N. S., Lo T. L., Guy G. R., Parsons S. J., Fan F., Platanias L. C., Mcgahren-Murray M., Keyomarsi K., Kos J., Seigel G. M., Alison M. R., Hiyama E., Renehan A.G., Potten C. S., Tang D. G., Foster P., Lin K., Bergelt C., Ronai Z., Cukierman E., Aumercier M., Hodson M., Lolis E., Mehta A., Chung F.-L., Glatt H., Oberthür A., Warnat P., Aranda S., Culig Z., Chung B. H., Shin Y.-B., Kim M., Grevenstein W. M. U., van Eijck C. H. J., Baker S. G., Kramer B. S., Mahotka C., Carbone M., Yang H., Mueller S. C., Coopman P. J., Brujin D., Kessel A. D., George J. M..
Squamous cell carcinoma.
https://doi.org/10.1007/978-3-642-16483-5
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Corbacioglu S., Steinbach D., Gruhn B., Frühwald Michael C., Strauss G., Suttorp M., Lode H. N., Escherich G., Cario G., Ehlert K., Meister B., Decarolis B., Broeckelmann M., Debatin K.-M., Ellinger S., Berthold F..
The rist design: a promising molecularly targeted multimodal approach for the treatment of patients with relapsed and refractory neuroblastoma.
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Frühwald Michael C., Rutkowski Stefan.
Tumors of the central nervous system in children and adolescents.
https://doi.org/10.3238/arztebl.2011.0390
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2010 |
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Hasselblatt M., Frühwald Michael C., Schneppenheim R., Oyen F., Kordes U., Gesk S., Siebert R., Paulus W..
BRG1 & CRINET: two exceptions to the equation AT/RT = inactivation of INI1.
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Kordes Uwe, Gesk Stefan, Frühwald Michael C., Graf Norbert, Leuschner Ivo, Hasselblatt Martin, Jeibmann Astrid, Oyen Florian, Peters Ove, Pietsch Torsten, Siebert Reiner, Schneppenheim Reinhard.
Clinical and molecular features in patients with atypical teratoid rhabdoid tumor or malignant rhabdoid tumor.
https://doi.org/10.1002/gcc.20729
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Muehlisch J., Ostermann B., Jürgens H., Frühwald Michael C..
Evaluation of DNA methylation in rhabdoid tumors.
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Schneppenheim Reinhard, Frühwald Michael C., Gesk Stefan, Hasselblatt Martin, Jeibmann Astrid, Kordes Uwe, Kreuz Markus, Leuschner Ivo, Subero Jose Ignacio Martin, Obser Tobias, Oyen Florian, Vater Inga, Siebert Reiner.
Germline nonsense mutation and somatic inactivation of SMARCA4/BRG1 in a family with rhabdoid tumor predisposition syndrome.
https://doi.org/10.1016/j.ajhg.2010.01.013
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Luenenbuerger H., Lanvers-Kaminsky C., Frühwald Michael C..
In vitro evaluation of novel and standard anti-cancer agents for rhabdoid tumors.
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Däbritz Jan, Worch Jennifer, Materna Ulrike, Koch Bernward, Koehler Gabriele, Duck Christina, Frühwald Michael C., Foell Dirk.
Life-threatening hypersplenism due to idiopathic portal hypertension in early childhood: case report and review of the literature.
https://doi.org/10.1186/1471-230x-10-122
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Schlosser S., Wagner S., Mühlisch J., Hasselblatt M., Gerss J., Wolff J., Frühwald Michael C..
MGMT as a potential stratification marker in relapsed high-grade glioma of children: the HIT-GBM experience.
https://doi.org/10.1002/pbc.22323
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Redlich A., Frühwald Michael C., Dralle H., Schweinitz D., Reiners C., Vorwerk P..
Maligne endokrine Tumoren im Kinder und Jugendalter.
https://doi.org/10.1055/s-0029-1245678
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Koos B., Peetz-Dienhart S., Riesmeier B., Frühwald Michael C., Hasselblatt M..
O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation is significantly less frequent in ependymal tumours as compared to malignant astrocytic gliomas.
https://doi.org/10.1111/j.1365-2990.2010.01077.x
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Baumann-Köhler M., Frühwald Michael C., Jürgens H..
Palliative Sedierung am Lebensende von Kindern und Jugendlichen mit Krebserkrankungen – eine Bestandsaufnahme.
https://doi.org/10.1055/s-0030-1265314
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Lünenbürger H., Lanvers-Kaminsky C., Lechtape B., Frühwald Michael C..
Systematic analysis of the antiproliferative effects of novel and standard anticancer agents in rhabdoid tumor cell lines.
https://doi.org/10.1097/cad.0b013e3283375d5c
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Frühwald Michael C., Krefeld B., Benesch B., Buechner J., Boos J., Ebetsberger E., Graf N., Kortmann R., Nysom K., Rutkowski S., Schneppenheim R., Siebert R., Timmermann B., Warmuth-Metz M., Hasselblatt M..
The European Rhabdoid Registry (EU-RHAB): a comprehensive approach towards biology and clinical management.
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Luenenbuerger H., Lanvers-Kaminsky C., Frühwald Michael C..
The cytotoxicity of novel and standard anti-cancer agents in rhabdoid tumor cell lines.
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Koos Björn, Jeibmann Astrid, Lünenbürger Henning, Mertsch Sonja, Nupponen Nina N., Roselli Annariikka, Leuschner Ivo, Paulus Werner, Frühwald Michael C., Hasselblatt Martin.
The tyrosine kinase c-Abl promotes proliferation and is expressed in atypical teratoid and malignant rhabdoid tumors.
https://doi.org/10.1002/cncr.25420
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Niemann A., Mühlisch J., Frühwald Michael C., Gerss J., Hempel G., Boos J..
Therapeutic drug monitoring of Methotrexate in cerebrospinal fluid after systemic high-dose infusion in children: can the burden of intrathecal methotrexate be reduced?.
https://doi.org/10.1097/ftd.0b013e3181e5c6b3
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Ghosh Srimoyee, Yates Allan J., Frühwald Michael C., Miecznikowski Jeffrey C., Plass Christoph, Smiraglia Dominic.
Tissue specific DNA methylation of CpG islands in normal human adult somatic tissues distinguishes neural from non-neural tissues.
https://doi.org/10.4161/epi.5.6.12228
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Mitchell Lesley, Lambers Moritz, Flege Silke, Kenet Gili, Li-Thiao-Te Valerie, Holzhauer Susanne, Bidlingmaier Christoph, Frühwald Michael C., Heller Christine, Schmidt Wolfgang, Pautard Brigitte, Nowak-Göttl Ulrike.
Validation of a predictive model for identifying an increased risk for thromboembolism in children with acute lymphoblastic leukemia: results of a multicenter cohort study.
https://doi.org/10.1182/blood-2010-01-263012
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2009 |
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Goedecke Simon, Schlosser Sabrina, Mühlisch Jörg, Hempel Georg, Frühwald Michael C., Wünsch Bernhard.
Accurate quantification of DNA methylation of DRD4 applying capillary gel electrophoresis with LIF detection.
https://doi.org/10.1002/elps.200800567
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Dorn I., Budde U., Frühwald Michael C., Poppelmann M., Nowak-Gottl U..
Acquired von Willebrand syndrome in a 10-year-old girl with acute lymphoblastic leukaemia.
https://doi.org/10.1136/bcr.04.2009.1816
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Hasselblatt M., Oyen F., Gesk S., Kordes U., Wrede B., Bergmann M., Schmid H., Frühwald Michael C., Schneppenheim R., Siebert R., Paulus W..
Cribriform Neuroepithelial Tumor (CRINET): a nonrhabdoid ventricular tumor with INI1 loss and relatively favorable prognosis.
https://doi.org/10.1097/NEN.0b013e3181c06a51
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Goedecke Simon, Schlosser Sabrina, Mühlisch Jörg, Hempel Georg, Frühwald Michael C., Wünsch Bernhard.
Determination of DNA methylation by COBRA: a comparative study of CGE with LIF detection and conventional gel electrophoresis.
https://doi.org/10.1002/elps.200900204
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Hayden James T., Frühwald Michael C., Hasselblatt Martin, Ellison David W., Bailey Simon, Clifford Steven C..
Frequent IDH1 mutations in supratentorial primitive neuroectodermal tumors (sPNET) of adults but not children.
https://doi.org/10.4161/cc.8.11.8594
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Jeibmann Astrid, Hasselblatt Martin, Pfister Stefan, Sträter Ronald, Brentrup Angela, Holling Markus, Niederstadt Thomas, Paulus Werner, Frühwald Michael C..
From glioblastoma to gangliocytoma: an unforeseen but welcome shift in biological behavior.
https://doi.org/10.3171/2009.6.peds097
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Brecht I. B., Graf N., Schweinitz D. von, Frühwald Michael C., Bielack S. S., Schneider D. T..
Networking for children and adolescents with very rare tumors: foundation of the GPOH Pediatric Rare Tumor Group.
https://doi.org/10.1055/s-0029-1220705
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2008 |
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Hasselblatt Martin, Mühlisch Jörg, Wrede Brigitte, Kallinger Birgit, Jeibmann Astrid, Peters Ove, Kutluk Tezer, Wolff Johannes E. A., Paulus Werner, Frühwald Michael C..
Aberrant MGMT (O6-methylguanine-DNA methyltransferase) promoter methylation in choroid plexus tumors.
https://doi.org/10.1007/s11060-008-9694-2
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Frühwald Michael C..
Medulloblastoma.
https://doi.org/10.1007/978-3-540-47648-1_3601
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Worch J., Ritter J., Frühwald Michael C..
Presentation of acute promyelocytic leukemia as granulocytic sarcoma.
https://doi.org/10.1002/pbc.21190
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Reinhard Harald, Reinert Jennifer, Beier Rita, Furtwängler Rhoikos, Alkasser Muhanat, Rutkowski Stefan, Frühwald Michael C., Koscielniak Ewa, Leuschner Ivo, Kaatsch Peter, Graf Norbert.
Rhabdoid tumors in children: prognostic factors in 70 patients diagnosed in Germany.
https://doi.org/10.3892/or.19.3.819
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Wittkowski H., Frosch M., Wulffraat N. M., Goldbach-Mansky R., Kallinich T., Kuemmerle-Deschner J., Frühwald Michael C., Dassmann S., Pham H., Roth J., Foell D..
S100A12 is a novel molecular marker differentiating systemic-onset juvenile idiopathic arthritis from other causes of fever of unknown origin.
https://doi.org/10.1002/art.24137
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Kerl K., Jung M., Jürgens H., Frühwald Michael C..
Selective inhibitors of histone deacetylases (HDI): a novel avenue for the treatment of rhabdoid tumors.
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Frühwald Michael C..
Somatostatin.
https://doi.org/10.1007/978-3-540-47648-1_5414
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Frühwald Michael C., Witt O..
The epigenetics of cancer in children.
https://doi.org/10.1055/s-0028-1086026
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Oommen P. T., Romahn A., Linden T., Frühwald Michael C., Bucsky P..
UICC-2002 TNM classification is not suitable for differentiated thyroid cancer in children and adolescents.
https://doi.org/10.1002/pbc.21385
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2007 |
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Ehlert K., Florax A., Worch J., Roessig C., Frühwald Michael C..
161: Severe veno-occlusive disease after bone marrow transplantation in premature monozygotic twins with familial hemophagocytic lymphohistiocytosis (FLH).
https://doi.org/10.1016/j.bbmt.2006.12.165
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Frühwald Michael C., Wagner S., Hasselblatt M., Muehlisch J., Wolff J., Jürgens H..
Aberrant methylation of O-6-MGMT in pediatric high-grade glioma: a surrogate marker for response to temozolomide?.
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Kreth J. H., Schlosser S., Lenschen T., Paulus W., Smiraglia D. J., Plass C., Jürgens H., Muehlisch J., Frühwald Michael C..
Epigenetic silencing of transcription factor genes in CNS malignancies of childhood.
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Mühlisch J., Bajanowski T., Rickert C. H., Roggendorf W., Würthwein G., Jürgens H., Frühwald Michael C..
Frequent but borderline methylation of p16INK4a and TIMP3 in medulloblastoma and sPNET revealed by quantitative analyses.
https://doi.org/10.1007/s11060-006-9309-8
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Furchert Sarah E., Lanvers-Kaminsky Claudia, Jürgens Heribert, Jung Manfred, Loidl Adele, Frühwald Michael C..
Inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood.
https://doi.org/10.1002/ijc.22401
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Dietlein M., Biermann M., Frühwald Michael C., Linden T., Bucsky P., Reiners C., Schober O., Franzius C..
Procedure guideline for radioiodine therapy and 131iodine whole-body scintigraphy in paediatric patients with differentiated thyroid cancer.
https://doi.org/10.1160/nukmed-0288
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Frühwald Michael C., Jürgens H., Siebert R., Hasselblatt M., Schneppenheim R..
Rhabdoid tumor predisposition without mutation of SMARCB1 (SNF5/INI1) in a family: evidence for a second genomic locus.
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Muehlisch J., Schwering A., Vince G. H., Soerensen N., Bajanowski T., Paulus W., Jürgens H., Frühwald Michael C..
Screening for candidate genes reveals RASSF1A as the only consistently methylated gene in malignant childhood brain tumors.
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Frühwald Michael C., Jürgens H., Paulus W., Straeter R..
Temozolomide in the management of high-risk medulloblastoma/PNET: a promising pilot experience.
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Simon Thorsten, Längler Alfred, Harnischmacher Urs, Frühwald Michael C., Jorch Norbert, Claviez Alexander, Berthold Frank, Hero Barbara.
Topotecan, cyclophosphamide, and etoposide (TCE) in the treatment of high-risk neuroblastoma: results of a phase-II trial.
https://doi.org/10.1007/s00432-007-0216-y
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2006 |
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Mühlisch J., Schwering A., Grotzer M., Vince G. H., Roggendorf W., Hagemann C., Sörensen N., Rickert C. H., Osada N., Jürgens H., Frühwald Michael C..
Epigenetic repression of RASSF1A but not CASP8 in supratentorial PNET (sPNET) and atypical teratoid/rhabdoid tumors (AT/RT) of childhood.
https://doi.org/10.1038/sj.onc.1209137
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Jeibmann Astrid, Buerger Horst, Frühwald Michael C., Hasselblatt Martin.
No evidence for epidermal growth factor receptor amplification and overexpression in atypical teratoid/rhabdoid tumors.
https://doi.org/10.1007/s00401-006-0120-6
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Frühwald Michael C., Hasselblatt M., Wirth S., Köhler G., Schneppenheim R., Subero J. I. M., Siebert R., Kordes U., Jürgens H., Vormoor J..
Non-linkage of familial rhabdoid tumors to SMARCB1 implies a second locus for the rhabdoid tumor predisposition syndrome.
https://doi.org/10.1002/pbc.20526
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2004 |
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Mühlisch J., Jürgens H., Frühwald Michael C..
Combination of different methodologies elucidates tumor specific methylation in medulloblastoma.
https://doi.org/10.1055/s-2004-828585
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Lenschen T., Mühlisch J., Jürgens H., Plass C., Smiraglia D., Frühwald Michael C..
In depth analysis of aberrantly methylated genes detected by genome scanning in medulloblastoma and other malignancies of the CNS.
https://doi.org/10.1055/s-2004-828580
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Lenschen T., Mühlisch J., Jürgens H., Plass C., Smiraglia D., Frühwald Michael C..
Reevaluation of gene amplification in medulloblastomas.
https://doi.org/10.1055/s-2004-828581
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Frühwald Michael C..
Somatostatin receptor subtype 2 is expressed by supratentorial primitive neuroectodermal tumors of childhood and can be targeted for somatostatin receptor imaging.
https://doi.org/10.1158/1078-0432.ccr-03-0083
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2003 |
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Frühwald Michael C..
DNA methylation patterns in cancer: novel prognostic indicators?.
https://doi.org/10.2165/00129785-200303040-00003
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2002 |
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Dai Z., Weichenhan D., Wu Y.-Z., Hall J. L., Rush L. J., Smith L. T., Raval A., Yu L., Kroll D., Muehlisch J., Frühwald Michael C., De Jong P., Catanese J., Davuluri R. V., Smiraglia D. J., Plass C..
An AscI boundary library for the studies of genetic and epigenetic alterations in CpG islands.
https://doi.org/10.1101/gr.197402
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Frühwald Michael C., Plass Christoph.
Global and gene-specific methylation patterns in cancer: aspects of tumor biology and clinical potential.
https://doi.org/10.1006/mgme.2001.3265
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Frühwald Michael C., Plass C..
Metastatic medulloblastoma - therapeutic success through molecular target identification?.
https://doi.org/10.1038/sj.tpj.6500077
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2001 |
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Frühwald Michael C., O'Dorisio M. S., Dai Z., Rush L. J., Krahe R., Smiraglia D. J., Pietsch T., Elsea S. H., Plass C..
Aberrant hypermethylation of the major breakpoint cluster region in 17p11.2 in medulloblastomas but not supratentorial PNETS.
https://doi.org/10.1002/1098-2264(2000)9999:9999<::AID-GCC1052>3.0.CO;2-S
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Frühwald Michael C., O'Dorisio M. Sue, Dai Zunyan, Tanner Stephan M., Balster Douglas A., Gao Xin, Wright Fred A., Plass Christoph.
Aberrant promoter methylation of previously unidentified target genes is a common abnormality in medulloblastomas–Implications for tumor biology and potential clinical utility.
https://doi.org/10.1038/sj.onc.1204613
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Plass Christoph, Frühwald Michael C., Rush Laura J., Dai Zunyan, Smith Laura T., Smiraglia Dominic J..
Contribution of DNA methylation to oncogenesis: results of a genome scanning approach in multiple human tumors.
https://doi.org/10.1038/87252
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Kögel D., Reimertz C., Mech P., Poppe M., Frühwald Michael C., Engemann H., Scheidtmann K. H., Prehn J. H. M..
Dlk/ZIP kinase-induced apoptosis in human medulloblastoma cells: requirement of the mitochondrial apoptosis pathway.
https://doi.org/10.1054/bjoc.2001.2158
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Smiraglia D. J., Rush L. J., Frühwald Michael C., Dai Z., Held W. A., Costello J., Lang J. C., Eng C., Li B., Wright F. A., Caligiuri M. A., Plass C..
Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies.
https://doi.org/10.1093/hmg/10.13.1413
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Dai Zunyan, Lakshmanan Romola R., Zhu Wei-Guo, Smiraglia Dominic J., Rush Laura J., Frühwald Michael C., Brena Romulo M., Li Bin, Wright Fred A., Ross Patrick, Otterson Gregory A., Plass Christoph.
Global methylation profiling of lung cancer identifies novel methylated genes.
https://doi.org/10.1038/sj.neo.7900162
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Frühwald Michael C., O'Dorisio M. S., Smith L., Dai Z., Wright F. A., Paulus W., Jürgens H., Plass C..
Hypermethylation as a potential prognostic factor and a clue to a better understanding of the molecular pathogenesis of Medulloblastoma - results of a genomewide methylation scan.
https://doi.org/10.1055/s-2001-16851
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Frühwald Michael C..
Medulloblastoma.
https://doi.org/10.1007/3-540-30683-8_1030
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Rush L. J., Dai Z., Smiraglia D. J., Gao X., Wright F. A., Frühwald Michael C., Costello J., Held W. A., Yu L., Krahe R., Kolitz J., Bloomfield C. D., Caligiuri M. A., Plass C..
Novel methylation targets in de novo acute myeloid leukemia with prevalence of chromosome 11 loci.
https://doi.org/10.1182/blood.v97.10.3226
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Frühwald Michael C..
Somatostatin.
https://doi.org/10.1007/3-540-30683-8_1561
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2000 |
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Costello Joseph F., Frühwald Michael C., Smiraglia Dominic J., Rush Laura J., Robertson Gavin P., Gao Xin, Wright Fred A., Feramisco Jamison D., Peltomäki Päivi, Lang James C., Schuller David E., Yu Li, Bloomfield Clara D., Caligiuri Michael A., Yates Allan, Nishikawa Ryo, Su Huang H.-J., Petrelli Nicholas J., Zhang Xueli, O'Dorisio M. S., Held William A., Cavenee Webster K., Plass Christoph.
Aberrant CpG-island methylation has non-random and tumour-type–specific patterns.
https://doi.org/10.1038/72785
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Frühwald Michael C., O'Dorisio M. S., Rush L. J., Reiter J. L., Smiraglia D. J., Wenger G., Costello J., White P. S., Krahe R., Brodeur G. M., Plass C..
Gene amplification in PNETs/medulloblastomas: mapping of a novel amplified gene within the MYCN amplicon.
https://doi.org/10.1136/jmg.37.7.501
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1999 |
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Smiraglia Dominic J., Frühwald Michael C., Costello Joseph F., McCormick Sean P., Dai Zunyan, Peltomäki Päivi, O'Dorisio M.Sue, Cavenee Webster K., Plass Christoph.
A new tool for the rapid cloning of amplified and hypermethylated human DNA sequences from restriction landmark genome scanning gels.
https://doi.org/10.1006/geno.1999.5840
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Frühwald Michael C., O'Dorisio M. Sue, Pietsch Torsten, Reubi Jean Claude.
High expression of somatostatin receptor subtype 2 (sst2) in medulloblastoma: implications for diagnosis and therapy.
https://doi.org/10.1203/00006450-199905010-00016
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Frühwald Michael C., O'Dorisio M. S., Fleitz J., Pietsch T., Reubi J. C..
Vasoactive intestinal peptide (VIP) and VIP receptors: gene expression and growth modulation in medulloblastoma and other central primitive neuroectodermal tumors of childhood.
https://doi.org/10.1002/(sici)1097-0215(19990412)81:2<165::aid-ijc1>3.0.co;2-0
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1998 |
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Müller H. L., Frühwald Michael C., Scheubeck M., Rendl J., Warmuth-Metz M., Sörensen N., Kühl J., Reubi J. C..
A possible role for somatostatin receptor (sstr) scintigraphy in the follow-up of children with medulloblastoma (MB).
https://doi.org/10.1023/A:1005961302340
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Frühwald Michael C., O'Doriso M. Sue, Cottingham Sandra L., Qualman Stephen J., O'Doriso Thomas M..
Neuropeptides in developmental tumors of the central and peripheral nervous system.
https://doi.org/10.1111/j.1749-6632.1998.tb11208.x
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